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UniProt functional annotation for P00326 | ||
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| UniProt code: P00326. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Catalytic activity: | |
Reaction=a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH; Xref=Rhea:RHEA:10736, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734, ChEBI:CHEBI:17478, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1; |
| Catalytic activity: | |
Reaction=a secondary alcohol + NAD(+) = a ketone + H(+) + NADH; Xref=Rhea:RHEA:10740, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087, ChEBI:CHEBI:35681, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.1; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.; |
| Subunit: | |
Dimer of identical or non-identical chains of three types; alpha, beta and gamma. {ECO:0000269|PubMed:11274460, ECO:0000269|PubMed:15449945}. |
| Subcellular location: | |
Cytoplasm. |
| Polymorphism: | |
Two main alleles are known, ADH3*1 or gamma-1 has Arg- 272/Ile-350 while ADH3*2 or gamma-2 has Gln-272/Val-350. ADH3*1 is associated with a fast rate of ethanol oxidation and ADH3*2 with a slow rate. {ECO:0000269|PubMed:3758060}. |
| Miscellaneous: | |
There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6. |
| Similarity: | |
Belongs to the zinc-containing alcohol dehydrogenase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.