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PDBsum entry 1d8s
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Top Page protein Protein-protein interface(s) tunnels links
Tunnel analysis for: 1d8s calculated with MOLE 2.0 PDB id
1d8s
Tunnels calculated on whole structure Tunnels calculated excluding ligands
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66 tunnels, coloured by tunnel radius 66 tunnels, coloured by tunnel radius 66 tunnels, coloured as in
list below
Tunnels are interior spaces connected with the protein surrounding. Only channels longer than 15 Å are shown.
Tunnels
Free R
Length
HPathy
HPhob
Polar
Rel Mut
Residue..type
Ligands
Radius
1 2.08 2.08 28.9 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 126 C UNK 127 C UNK 128 C UNK 131 C UNK 132 C
UNK 166 C UNK 167 C UNK 251 C UNK 252 C UNK 255 C
UNK 259 C UNK 266 C UNK 268 C UNK 271 C UNK 302 C
UNK 305 C UNK 306 C UNK 308 C UNK 309 C UNK 323 C
UNK 325 C UNK 326 C UNK 327 C UNK 342 C
2 3.51 3.51 30.4 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 341 C UNK 344 C UNK 346 C UNK 373 C UNK 374 C
UNK 377 C UNK 159 D UNK 163 D UNK 164 D UNK 187 D
UNK 188 D UNK 189 D UNK 192 D UNK 195 D UNK 257 D
UNK 259 D UNK 260 D UNK 311 D UNK 313 D UNK 420 D
UNK 423 D
3 2.51 2.51 35.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 67 C UNK 286 C UNK 287 C UNK 296 C UNK 297 C
UNK 299 C UNK 300 C UNK 341 C UNK 17 D UNK 18 D
UNK 19 D UNK 187 D UNK 226 D UNK 259 D UNK 260 D
UNK 263 D UNK 264 D UNK 267 D UNK 271 D UNK 311 D
UNK 313 D UNK 285 G
4 2.68 2.68 38.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 130 C UNK 131 C UNK 132 C UNK 297 C UNK 299 C
UNK 300 C UNK 304 C UNK 341 C UNK 18 D UNK 19 D
UNK 43 D UNK 65 D UNK 67 D UNK 187 D UNK 223 D
UNK 225 D UNK 226 D UNK 259 D UNK 260 D UNK 263 D
UNK 264 D UNK 267 D UNK 311 D UNK 313 D
5 2.41 2.41 38.1 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 166 C UNK 167 C UNK 168 C UNK 325 C UNK 327 C
UNK 334 C UNK 339 C UNK 343 C UNK 346 C UNK 348 C
UNK 349 C UNK 369 C UNK 373 C UNK 374 C UNK 377 C
UNK 158 D UNK 159 D UNK 163 D UNK 164 D UNK 189 D
UNK 192 D UNK 195 D UNK 420 D UNK 423 D
6 2.60 2.60 39.1 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 166 C UNK 167 C UNK 168 C UNK 325 C UNK 327 C
UNK 332 C UNK 334 C UNK 335 C UNK 339 C UNK 343 C
UNK 349 C UNK 355 C UNK 356 C UNK 359 C UNK 366 C
UNK 369 C UNK 398 C UNK 401 C UNK 402 C UNK 158 D
UNK 337 D UNK 338 D UNK 380 F UNK 383 F UNK 400 F
7 2.17 2.17 40.7 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 341 C UNK 344 C UNK 163 D UNK 166 D UNK 170 D
UNK 175 D UNK 176 D UNK 183 D UNK 187 D UNK 188 D
UNK 189 D UNK 192 D UNK 196 D UNK 200 D UNK 203 D
UNK 204 D UNK 205 D UNK 215 D UNK 256 D UNK 257 D
UNK 259 D UNK 260 D UNK 311 D UNK 313 D
8 2.15 2.15 41.7 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 36 A UNK 78 A UNK 79 A UNK 237 A UNK 33 D UNK
50 D UNK 117 D UNK 118 D UNK 119 D UNK 259 D UNK
262 D UNK 263 D UNK 265 D UNK 266 D UNK 281 D UNK
282 D UNK 284 D UNK 285 D UNK 288 D UNK 291 D UNK
311 D UNK 313 D UNK 321 D
9 2.35 2.35 42.3 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 64 C UNK 65 C UNK 67 C UNK 69 C UNK 166 C UNK
167 C UNK 244 C UNK 247 C UNK 271 C UNK 274 C UNK
278 C UNK 282 C UNK 285 C UNK 286 C UNK 287 C UNK
297 C UNK 301 C UNK 302 C UNK 325 C UNK 326 C UNK
327 C UNK 342 C UNK 17 D UNK 18 D
10 1.97 1.97 42.8 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 98 C UNK 102 C UNK 103 C UNK 104 C UNK 105 C
UNK 106 C UNK 108 C UNK 112 C UNK 114 C UNK 118 C
UNK 119 C UNK 121 C UNK 166 C UNK 167 C UNK 202 C
UNK 203 C UNK 204 C UNK 230 C UNK 232 C UNK 247 C
UNK 250 C UNK 251 C UNK 253 C UNK 266 C UNK 267 C
UNK 268 C UNK 271 C UNK 302 C UNK 305 C UNK 306 C
UNK 325 C UNK 326 C UNK 327 C UNK 342 C
11 1.97 1.97 43.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 100 C UNK 101 C UNK 104 C UNK 166 C UNK 167 C
UNK 190 C UNK 195 C UNK 200 C UNK 201 C UNK 202 C
UNK 203 C UNK 204 C UNK 228 C UNK 230 C UNK 232 C
UNK 247 C UNK 250 C UNK 251 C UNK 253 C UNK 266 C
UNK 267 C UNK 268 C UNK 271 C UNK 302 C UNK 305 C
UNK 306 C UNK 325 C UNK 326 C UNK 327 C UNK 342 C
12 2.47 2.47 43.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 134 C UNK 135 C UNK 138 C UNK 162 C UNK 258 C
UNK 259 C UNK 308 C UNK 309 C UNK 310 C UNK 311 C
UNK 312 C UNK 316 C UNK 341 C UNK 344 C UNK 346 C
UNK 347 C UNK 373 C UNK 159 D UNK 163 D UNK 187 D
UNK 188 D UNK 189 D UNK 191 D UNK 192 D UNK 257 D
UNK 259 D UNK 260 D UNK 311 D UNK 313 D
13 3.51 3.51 43.5 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 330 A UNK 331 A UNK 332 A UNK 333 A UNK 337 C
UNK 341 C UNK 259 D UNK 260 D UNK 263 D UNK 279 D
UNK 311 D UNK 313 D UNK 314 D UNK 316 D UNK 318 D
UNK 319 D UNK 314 E UNK 3 G UNK 7 G UNK 10 G UNK
11 G UNK 264 G UNK 268 G UNK 271 G
14 3.01 3.01 44.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 341 C UNK 344 C UNK 148 D UNK 149 D UNK 163 D
UNK 166 D UNK 169 D UNK 170 D UNK 173 D UNK 174 D
UNK 177 D UNK 182 D UNK 183 D UNK 187 D UNK 188 D
UNK 189 D UNK 192 D UNK 196 D UNK 250 D UNK 251 D
UNK 252 D UNK 254 D UNK 256 D UNK 257 D UNK 259 D
UNK 260 D UNK 305 D UNK 311 D UNK 313 D
15 2.35 2.35 44.5 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 50 C UNK 60 C UNK 61 C UNK 62 C UNK 64 C UNK
95 C UNK 96 C UNK 110 C UNK 111 C UNK 166 C UNK
167 C UNK 241 C UNK 244 C UNK 245 C UNK 247 C UNK
271 C UNK 274 C UNK 278 C UNK 301 C UNK 302 C UNK
325 C UNK 326 C UNK 327 C UNK 342 C
16 2.94 2.94 44.9 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 341 C UNK 344 C UNK 346 C UNK 372 C UNK 373 C
UNK 389 C UNK 392 C UNK 159 D UNK 160 D UNK 161 D
UNK 163 D UNK 164 D UNK 187 D UNK 188 D UNK 189 D
UNK 257 D UNK 259 D UNK 260 D UNK 311 D UNK 313 D
UNK 340 D UNK 343 D UNK 345 D UNK 424 D UNK 425 D
UNK 455 D UNK 458 D UNK 459 D UNK 473 D
17 2.57 2.57 45.2 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 166 C UNK 167 C UNK 168 C UNK 325 C UNK 327 C
UNK 331 C UNK 332 C UNK 334 C UNK 335 C UNK 339 C
UNK 343 C UNK 349 C UNK 369 C UNK 398 C UNK 402 C
UNK 158 D UNK 337 D UNK 338 D UNK 338 F UNK 382 F
UNK 383 F UNK 385 F UNK 386 F UNK 1 G UNK 5 G UNK
259 G
18 3.48 3.48 46.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 330 A UNK 332 A UNK 333 A UNK 334 A UNK 335 A
UNK 336 A UNK 369 A UNK 337 C UNK 341 C UNK 259 D
UNK 260 D UNK 263 D UNK 279 D UNK 311 D UNK 313 D
UNK 314 D UNK 316 D UNK 318 D UNK 319 D UNK 314 E
UNK 315 E UNK 3 G UNK 268 G UNK 271 G
19 2.69 2.69 46.3 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 50 C UNK 60 C UNK 61 C UNK 62 C UNK 64 C UNK
95 C UNK 96 C UNK 110 C UNK 111 C UNK 130 C UNK
241 C UNK 244 C UNK 245 C UNK 297 C UNK 299 C UNK
300 C UNK 301 C UNK 341 C UNK 18 D UNK 19 D UNK
65 D UNK 187 D UNK 225 D UNK 226 D UNK 259 D UNK
260 D UNK 263 D UNK 264 D UNK 267 D UNK 311 D UNK
313 D
20 2.60 2.60 46.5 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 355 A UNK 356 A UNK 166 C UNK 167 C UNK 168 C
UNK 325 C UNK 327 C UNK 334 C UNK 335 C UNK 339 C
UNK 343 C UNK 349 C UNK 369 C UNK 158 D UNK 314 D
UNK 315 D UNK 336 D UNK 337 D UNK 338 D UNK 351 D
UNK 382 D UNK 383 D UNK 4 G UNK 5 G UNK 7 G UNK 8
G UNK 11 G UNK 15 G
21 2.32 2.32 47.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 50 C UNK 64 C UNK 130 C UNK 131 C UNK 132 C
UNK 166 C UNK 167 C UNK 244 C UNK 247 C UNK 271 C
UNK 274 C UNK 278 C UNK 300 C UNK 301 C UNK 302 C
UNK 304 C UNK 325 C UNK 326 C UNK 327 C UNK 342 C
UNK 18 D UNK 43 D UNK 65 D UNK 67 D UNK 223 D
22 2.54 2.54 48.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 331 A UNK 332 A UNK 353 A UNK 355 A UNK 166 C
UNK 167 C UNK 168 C UNK 325 C UNK 327 C UNK 334 C
UNK 335 C UNK 339 C UNK 343 C UNK 349 C UNK 369 C
UNK 158 D UNK 314 D UNK 315 D UNK 336 D UNK 337 D
UNK 338 D UNK 351 D UNK 4 G UNK 5 G UNK 7 G UNK
11 G
23 3.47 3.47 48.6 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 332 B UNK 333 B UNK 335 B UNK 292 C UNK 337 C
UNK 341 C UNK 259 D UNK 260 D UNK 263 D UNK 279 D
UNK 311 D UNK 313 D UNK 314 D UNK 314 F UNK 315 F
UNK 316 F UNK 318 F UNK 338 F UNK 1 G UNK 2 G UNK
3 G UNK 259 G UNK 263 G UNK 266 G UNK 267 G UNK
270 G UNK 271 G UNK 274 G
24 2.34 2.34 52.4 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 286 B UNK 288 B UNK 289 B UNK 166 C UNK 167 C
UNK 271 C UNK 272 C UNK 292 C UNK 325 C UNK 326 C
UNK 327 C UNK 328 C UNK 330 C UNK 336 C UNK 338 C
UNK 339 C UNK 342 C UNK 273 F UNK 275 F UNK 276 F
UNK 277 F UNK 278 F UNK 279 F UNK 318 F UNK 274 G
UNK 277 G UNK 281 G UNK 284 G
25 2.04 2.04 53.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 87 D UNK 88 D UNK 179 D UNK 180 D UNK 181 D
UNK 182 D UNK 233 D UNK 237 D UNK 239 D UNK 240 D
UNK 243 D UNK 247 D UNK 251 D UNK 252 D UNK 253 D
UNK 255 D UNK 258 D UNK 259 D UNK 262 D UNK 263 D
UNK 289 D UNK 293 D UNK 296 D UNK 304 D UNK 308 D
UNK 311 D UNK 313 D UNK 321 D UNK 325 D
26 2.72 2.72 54.7 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 286 B UNK 288 B UNK 289 B UNK 292 C UNK 337 C
UNK 341 C UNK 259 D UNK 260 D UNK 263 D UNK 279 D
UNK 311 D UNK 313 D UNK 314 D UNK 273 F UNK 275 F
UNK 276 F UNK 277 F UNK 278 F UNK 279 F UNK 318 F
UNK 1 G UNK 2 G UNK 3 G UNK 271 G UNK 274 G UNK
277 G UNK 281 G UNK 284 G
27 2.15 2.15 54.8 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 166 C UNK 167 C UNK 168 C UNK 325 C UNK 327 C
UNK 334 C UNK 339 C UNK 343 C UNK 346 C UNK 348 C
UNK 349 C UNK 369 C UNK 373 C UNK 158 D UNK 159 D
UNK 163 D UNK 166 D UNK 170 D UNK 175 D UNK 176 D
UNK 183 D UNK 189 D UNK 192 D UNK 196 D UNK 200 D
UNK 203 D UNK 204 D UNK 205 D UNK 215 D UNK 256 D
28 1.37 1.37 56.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 166 C UNK 167 C UNK 168 C UNK 325 C UNK 327 C
UNK 332 C UNK 334 C UNK 335 C UNK 339 C UNK 343 C
UNK 349 C UNK 369 C UNK 398 C UNK 402 C UNK 158 D
UNK 337 D UNK 338 D UNK 386 D UNK 389 D UNK 390 D
UNK 383 F UNK 386 F UNK 5 G UNK 9 G UNK 13 G UNK
16 G UNK 17 G UNK 249 G UNK 250 G UNK 253 G
29 2.35 2.35 56.7 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 107 C UNK 116 C UNK 166 C UNK 167 C UNK 171 C
UNK 172 C UNK 176 C UNK 203 C UNK 205 C UNK 208 C
UNK 212 C UNK 213 C UNK 214 C UNK 216 C UNK 217 C
UNK 231 C UNK 269 C UNK 270 C UNK 271 C UNK 272 C
UNK 273 C UNK 292 C UNK 325 C UNK 326 C UNK 327 C
UNK 328 C UNK 338 C UNK 339 C UNK 342 C UNK 123 F
UNK 124 F UNK 318 F UNK 323 F UNK 327 F
30 2.36 2.36 57.2 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 36 C UNK 78 C UNK 79 C UNK 80 C UNK 81 C UNK
166 C UNK 167 C UNK 239 C UNK 240 C UNK 271 C UNK
272 C UNK 276 C UNK 277 C UNK 280 C UNK 292 C UNK
325 C UNK 326 C UNK 327 C UNK 328 C UNK 338 C UNK
339 C UNK 342 C UNK 117 F UNK 118 F UNK 119 F UNK
283 F UNK 284 F UNK 286 F UNK 287 F UNK 291 F UNK
318 F UNK 320 F UNK 324 F
31 2.34 2.34 58.4 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 166 C UNK 167 C UNK 171 C UNK 172 C UNK 176 C
UNK 177 C UNK 208 C UNK 212 C UNK 215 C UNK 216 C
UNK 219 C UNK 222 C UNK 270 C UNK 271 C UNK 272 C
UNK 273 C UNK 292 C UNK 325 C UNK 326 C UNK 327 C
UNK 328 C UNK 338 C UNK 339 C UNK 342 C UNK 128 F
UNK 318 F UNK 323 F UNK 327 F UNK 356 F UNK 361 F
32 2.22 2.22 58.7 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 64 A UNK 67 A UNK 272 A UNK 275 A UNK 276 A
UNK 278 A UNK 279 A UNK 282 A UNK 285 A UNK 286 A
UNK 287 A UNK 292 A UNK 294 A UNK 295 A UNK 297 A
UNK 298 A UNK 328 A UNK 336 A UNK 337 A UNK 338 A
UNK 337 C UNK 341 C UNK 259 D UNK 260 D UNK 263 D
UNK 279 D UNK 311 D UNK 313 D UNK 314 D UNK 316 D
UNK 318 D UNK 319 D UNK 15 E UNK 17 E UNK 18 E
UNK 20 E UNK 271 E UNK 3 G UNK 271 G
33 2.59 2.59 58.8 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 166 C UNK 167 C UNK 168 C UNK 325 C UNK 327 C
UNK 332 C UNK 334 C UNK 335 C UNK 339 C UNK 343 C
UNK 349 C UNK 369 C UNK 389 C UNK 392 C UNK 393 C
UNK 396 C UNK 398 C UNK 399 C UNK 400 C UNK 402 C
UNK 158 D UNK 337 D UNK 338 D UNK 342 D UNK 385 D
UNK 386 D UNK 408 D UNK 455 D UNK 458 D UNK 469 D
UNK 5 G
34 2.57 2.57 60.1 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 166 C UNK 167 C UNK 168 C UNK 325 C UNK 327 C
UNK 332 C UNK 334 C UNK 335 C UNK 339 C UNK 343 C
UNK 349 C UNK 369 C UNK 398 C UNK 399 C UNK 402 C
UNK 403 C UNK 408 C UNK 409 C UNK 158 D UNK 337 D
UNK 338 D UNK 385 D UNK 386 D UNK 388 D UNK 393 D
UNK 398 D UNK 401 D UNK 404 D UNK 408 D UNK 5 G
UNK 9 G
35 2.58 2.58 60.4 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 166 C UNK 167 C UNK 168 C UNK 325 C UNK 327 C
UNK 332 C UNK 334 C UNK 335 C UNK 339 C UNK 343 C
UNK 349 C UNK 369 C UNK 398 C UNK 399 C UNK 400 C
UNK 402 C UNK 403 C UNK 408 C UNK 409 C UNK 411 C
UNK 414 C UNK 158 D UNK 337 D UNK 338 D UNK 385 D
UNK 386 D UNK 398 D UNK 401 D UNK 404 D UNK 405 D
UNK 408 D UNK 450 D UNK 451 D UNK 452 D UNK 454 D
UNK 5 G
36 2.54 2.54 61.1 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 166 C UNK 167 C UNK 168 C UNK 325 C UNK 327 C
UNK 334 C UNK 339 C UNK 343 C UNK 348 C UNK 349 C
UNK 369 C UNK 371 C UNK 372 C UNK 373 C UNK 133 D
UNK 135 D UNK 137 D UNK 140 D UNK 146 D UNK 148 D
UNK 149 D UNK 158 D UNK 159 D UNK 161 D UNK 164 D
UNK 165 D UNK 169 D UNK 173 D UNK 177 D UNK 250 D
UNK 251 D UNK 305 D UNK 307 D UNK 345 D UNK 346 D
UNK 416 D UNK 418 D UNK 421 D UNK 424 D
37 2.01 2.01 63.9 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 31 C UNK 39 C UNK 41 C UNK 44 C UNK 47 C UNK
48 C UNK 49 C UNK 50 C UNK 53 C UNK 55 C UNK 56 C
UNK 63 C UNK 66 C UNK 71 C UNK 73 C UNK 81 C UNK
82 C UNK 83 C UNK 86 C UNK 88 C UNK 130 C UNK 297
C UNK 299 C UNK 300 C UNK 341 C UNK 16 D UNK 18 D
UNK 19 D UNK 65 D UNK 66 D UNK 67 D UNK 69 D UNK
187 D UNK 225 D UNK 226 D UNK 259 D UNK 260 D UNK
263 D UNK 264 D UNK 267 D UNK 311 D UNK 313 D
38 2.44 2.44 64.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 151 C UNK 152 C UNK 155 C UNK 156 C UNK 166 C
UNK 167 C UNK 168 C UNK 325 C UNK 327 C UNK 332 C
UNK 334 C UNK 335 C UNK 339 C UNK 343 C UNK 349 C
UNK 355 C UNK 356 C UNK 365 C UNK 366 C UNK 367 C
UNK 369 C UNK 390 C UNK 394 C UNK 398 C UNK 424 C
UNK 425 C UNK 427 C UNK 428 C UNK 429 C UNK 430 C
UNK 431 C UNK 434 C UNK 436 C UNK 440 C UNK 441 C
UNK 445 C UNK 465 C UNK 466 C UNK 158 D UNK 337 D
UNK 338 D
39 2.73 2.73 64.6 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 107 C UNK 116 C UNK 171 C UNK 172 C UNK 176 C
UNK 203 C UNK 205 C UNK 208 C UNK 212 C UNK 213 C
UNK 214 C UNK 216 C UNK 217 C UNK 231 C UNK 269 C
UNK 270 C UNK 272 C UNK 273 C UNK 275 C UNK 291 C
UNK 292 C UNK 294 C UNK 296 C UNK 298 C UNK 299 C
UNK 328 C UNK 337 C UNK 338 C UNK 341 C UNK 259 D
UNK 260 D UNK 263 D UNK 311 D UNK 313 D UNK 123 F
UNK 124 F UNK 318 F UNK 323 F UNK 327 F
40 2.43 2.43 65.2 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 36 C UNK 78 C UNK 79 C UNK 80 C UNK 81 C UNK
239 C UNK 240 C UNK 272 C UNK 275 C UNK 276 C UNK
277 C UNK 280 C UNK 291 C UNK 292 C UNK 294 C UNK
296 C UNK 298 C UNK 299 C UNK 328 C UNK 337 C UNK
338 C UNK 341 C UNK 259 D UNK 260 D UNK 263 D UNK
311 D UNK 313 D UNK 117 F UNK 118 F UNK 119 F UNK
283 F UNK 284 F UNK 286 F UNK 287 F UNK 291 F UNK
318 F UNK 320 F UNK 324 F
41 3.23 3.23 66.3 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 171 C UNK 172 C UNK 176 C UNK 177 C UNK 208 C
UNK 212 C UNK 215 C UNK 216 C UNK 219 C UNK 222 C
UNK 270 C UNK 272 C UNK 273 C UNK 275 C UNK 291 C
UNK 292 C UNK 294 C UNK 296 C UNK 298 C UNK 299 C
UNK 328 C UNK 337 C UNK 338 C UNK 341 C UNK 259 D
UNK 260 D UNK 263 D UNK 311 D UNK 313 D UNK 128 F
UNK 318 F UNK 323 F UNK 327 F UNK 356 F UNK 361 F
42 2.05 2.05 68.4 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 31 C UNK 39 C UNK 41 C UNK 44 C UNK 47 C UNK
48 C UNK 49 C UNK 50 C UNK 53 C UNK 55 C UNK 56 C
UNK 63 C UNK 64 C UNK 66 C UNK 71 C UNK 73 C UNK
81 C UNK 82 C UNK 83 C UNK 86 C UNK 88 C UNK 166
C UNK 167 C UNK 244 C UNK 247 C UNK 271 C UNK 274
C UNK 278 C UNK 301 C UNK 302 C UNK 325 C UNK 326
C UNK 327 C UNK 342 C UNK 16 D UNK 18 D UNK 66 D
UNK 69 D
43 3.25 3.25 68.9 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 171 C UNK 172 C UNK 174 C UNK 176 C UNK 177 C
UNK 208 C UNK 212 C UNK 270 C UNK 272 C UNK 273 C
UNK 275 C UNK 291 C UNK 292 C UNK 294 C UNK 296 C
UNK 298 C UNK 299 C UNK 328 C UNK 337 C UNK 338 C
UNK 341 C UNK 357 C UNK 360 C UNK 362 C UNK 430 C
UNK 432 C UNK 259 D UNK 260 D UNK 263 D UNK 311 D
UNK 313 D UNK 318 F UNK 323 F UNK 327 F UNK 356 F
UNK 358 F UNK 368 F UNK 369 F UNK 372 F
44 2.36 2.36 69.2 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 78 A UNK 79 A UNK 237 A UNK 64 C UNK 166 C
UNK 167 C UNK 244 C UNK 247 C UNK 271 C UNK 274 C
UNK 278 C UNK 282 C UNK 297 C UNK 300 C UNK 301 C
UNK 302 C UNK 325 C UNK 326 C UNK 327 C UNK 342 C
UNK 18 D UNK 19 D UNK 33 D UNK 49 D UNK 50 D UNK
61 D UNK 117 D UNK 118 D UNK 119 D UNK 225 D UNK
226 D UNK 227 D UNK 230 D UNK 265 D UNK 267 D UNK
268 D UNK 288 D UNK 291 D
45 3.47 3.47 73.4 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 171 A UNK 172 A UNK 176 A UNK 177 A UNK 206 A
UNK 212 A UNK 215 A UNK 216 A UNK 219 A UNK 222 A
UNK 270 A UNK 272 A UNK 273 A UNK 292 A UNK 328 A
UNK 336 A UNK 337 A UNK 433 A UNK 337 C UNK 341 C
UNK 259 D UNK 260 D UNK 263 D UNK 279 D UNK 311 D
UNK 313 D UNK 314 D UNK 316 D UNK 318 D UNK 319 D
UNK 320 D UNK 323 D UNK 324 D UNK 327 D UNK 356 D
UNK 359 D UNK 361 D UNK 3 G UNK 271 G
46 2.18 2.18 75.1 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 152 C UNK 155 C UNK 156 C UNK 166 C UNK 167 C
UNK 168 C UNK 325 C UNK 327 C UNK 332 C UNK 334 C
UNK 335 C UNK 339 C UNK 343 C UNK 349 C UNK 355 C
UNK 356 C UNK 365 C UNK 366 C UNK 367 C UNK 369 C
UNK 387 C UNK 390 C UNK 394 C UNK 398 C UNK 423 C
UNK 424 C UNK 425 C UNK 427 C UNK 444 C UNK 445 C
UNK 448 C UNK 452 C UNK 453 C UNK 455 C UNK 456 C
UNK 461 C UNK 464 C UNK 505 C UNK 506 C UNK 158 D
UNK 337 D UNK 338 D
47 2.11 2.11 76.6 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 128 A UNK 131 A UNK 132 A UNK 247 A UNK 251 A
UNK 252 A UNK 255 A UNK 266 A UNK 268 A UNK 271 A
UNK 272 A UNK 275 A UNK 276 A UNK 292 A UNK 294 A
UNK 298 A UNK 302 A UNK 305 A UNK 306 A UNK 308 A
UNK 309 A UNK 323 A UNK 325 A UNK 328 A UNK 336 A
UNK 337 A UNK 338 A UNK 342 A UNK 337 C UNK 341 C
UNK 259 D UNK 260 D UNK 263 D UNK 279 D UNK 311 D
UNK 313 D UNK 314 D UNK 316 D UNK 318 D UNK 319 D
UNK 3 G UNK 271 G
48 2.20 2.20 78.8 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 166 C UNK 167 C UNK 168 C UNK 325 C UNK 327 C
UNK 332 C UNK 334 C UNK 335 C UNK 339 C UNK 343 C
UNK 349 C UNK 369 C UNK 398 C UNK 399 C UNK 402 C
UNK 132 D UNK 138 D UNK 139 D UNK 141 D UNK 142 D
UNK 158 D UNK 337 D UNK 338 D UNK 339 D UNK 350 D
UNK 362 D UNK 363 D UNK 367 D UNK 370 D UNK 371 D
UNK 374 D UNK 378 D UNK 381 D UNK 382 D UNK 385 D
UNK 386 D UNK 408 D UNK 410 D UNK 411 D UNK 434 D
UNK 435 D UNK 437 D UNK 438 D UNK 441 D UNK 5 G
49 3.51 3.51 78.9 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 171 A UNK 172 A UNK 174 A UNK 176 A UNK 177 A
UNK 206 A UNK 212 A UNK 270 A UNK 272 A UNK 273 A
UNK 292 A UNK 328 A UNK 336 A UNK 337 A UNK 360 A
UNK 362 A UNK 430 A UNK 432 A UNK 462 A UNK 337 C
UNK 341 C UNK 259 D UNK 260 D UNK 263 D UNK 279 D
UNK 311 D UNK 313 D UNK 314 D UNK 316 D UNK 318 D
UNK 319 D UNK 320 D UNK 323 D UNK 324 D UNK 327 D
UNK 356 D UNK 358 D UNK 368 D UNK 369 D UNK 372 D
UNK 3 G UNK 271 G
50 2.12 2.12 80.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 101 A UNK 171 A UNK 172 A UNK 176 A UNK 180 A
UNK 183 A UNK 186 A UNK 190 A UNK 195 A UNK 198 A
UNK 199 A UNK 200 A UNK 201 A UNK 203 A UNK 204 A
UNK 205 A UNK 206 A UNK 208 A UNK 212 A UNK 216 A
UNK 220 A UNK 225 A UNK 228 A UNK 229 A UNK 269 A
UNK 270 A UNK 272 A UNK 273 A UNK 292 A UNK 328 A
UNK 336 A UNK 337 A UNK 337 C UNK 341 C UNK 259 D
UNK 260 D UNK 263 D UNK 279 D UNK 311 D UNK 313 D
UNK 314 D UNK 316 D UNK 318 D UNK 319 D UNK 320 D
UNK 323 D UNK 324 D UNK 327 D UNK 3 G UNK 271 G
51 2.28 2.28 81.6 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 105 A UNK 106 A UNK 107 A UNK 116 A UNK 118 A
UNK 171 A UNK 172 A UNK 176 A UNK 203 A UNK 204 A
UNK 205 A UNK 206 A UNK 208 A UNK 212 A UNK 213 A
UNK 214 A UNK 216 A UNK 217 A UNK 231 A UNK 269 A
UNK 270 A UNK 272 A UNK 273 A UNK 292 A UNK 328 A
UNK 336 A UNK 337 A UNK 337 C UNK 341 C UNK 259 D
UNK 260 D UNK 263 D UNK 279 D UNK 311 D UNK 313 D
UNK 314 D UNK 316 D UNK 318 D UNK 319 D UNK 320 D
UNK 323 D UNK 324 D UNK 327 D UNK 3 G UNK 271 G
52 2.42 2.42 81.6 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 36 B UNK 78 B UNK 79 B UNK 80 B UNK 81 B UNK
237 B UNK 239 B UNK 240 B UNK 272 B UNK 273 B UNK
276 B UNK 277 B UNK 292 B UNK 328 B UNK 330 B UNK
336 B UNK 337 B UNK 166 C UNK 167 C UNK 271 C UNK
272 C UNK 292 C UNK 325 C UNK 326 C UNK 327 C UNK
328 C UNK 330 C UNK 336 C UNK 338 C UNK 339 C UNK
342 C UNK 117 E UNK 118 E UNK 119 E UNK 283 E UNK
284 E UNK 286 E UNK 287 E UNK 291 E UNK 318 E UNK
320 E UNK 324 E UNK 314 F UNK 316 F UNK 318 F UNK
1 G UNK 266 G UNK 270 G UNK 274 G
53 2.44 2.44 83.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 36 B UNK 78 B UNK 79 B UNK 80 B UNK 81 B UNK
237 B UNK 239 B UNK 240 B UNK 272 B UNK 273 B UNK
276 B UNK 277 B UNK 292 B UNK 328 B UNK 330 B UNK
336 B UNK 337 B UNK 292 C UNK 337 C UNK 341 C UNK
259 D UNK 260 D UNK 263 D UNK 279 D UNK 311 D UNK
313 D UNK 314 D UNK 117 E UNK 118 E UNK 119 E UNK
283 E UNK 284 E UNK 286 E UNK 287 E UNK 291 E UNK
318 E UNK 320 E UNK 324 E UNK 314 F UNK 316 F UNK
318 F UNK 1 G UNK 2 G UNK 3 G UNK 266 G UNK 270 G
UNK 271 G UNK 274 G
54 2.37 2.37 84.3 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 130 B UNK 132 B UNK 291 B UNK 296 B UNK 297 B
UNK 299 B UNK 300 B UNK 166 C UNK 167 C UNK 271 C
UNK 272 C UNK 292 C UNK 325 C UNK 326 C UNK 327 C
UNK 328 C UNK 330 C UNK 336 C UNK 338 C UNK 339 C
UNK 342 C UNK 18 F UNK 43 F UNK 65 F UNK 223 F
UNK 225 F UNK 226 F UNK 263 F UNK 264 F UNK 279 F
UNK 313 F UNK 316 F UNK 318 F UNK 319 F UNK 1 G
UNK 270 G UNK 274 G
55 2.68 2.68 85.8 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 130 B UNK 132 B UNK 291 B UNK 296 B UNK 297 B
UNK 299 B UNK 300 B UNK 292 C UNK 337 C UNK 341 C
UNK 259 D UNK 260 D UNK 263 D UNK 279 D UNK 311 D
UNK 313 D UNK 314 D UNK 18 F UNK 43 F UNK 65 F
UNK 223 F UNK 225 F UNK 226 F UNK 263 F UNK 264 F
UNK 279 F UNK 313 F UNK 316 F UNK 318 F UNK 319 F
UNK 1 G UNK 2 G UNK 3 G UNK 270 G UNK 271 G UNK
274 G
56 2.40 2.40 87.6 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 171 B UNK 172 B UNK 174 B UNK 176 B UNK 177 B
UNK 207 B UNK 208 B UNK 212 B UNK 270 B UNK 272 B
UNK 273 B UNK 292 B UNK 328 B UNK 330 B UNK 336 B
UNK 337 B UNK 360 B UNK 362 B UNK 430 B UNK 432 B
UNK 166 C UNK 167 C UNK 271 C UNK 272 C UNK 292 C
UNK 325 C UNK 326 C UNK 327 C UNK 328 C UNK 330 C
UNK 336 C UNK 338 C UNK 339 C UNK 342 C UNK 318 E
UNK 320 E UNK 323 E UNK 324 E UNK 327 E UNK 356 E
UNK 358 E UNK 359 E UNK 360 E UNK 314 F UNK 316 F
UNK 318 F UNK 1 G UNK 266 G UNK 270 G UNK 274 G
57 2.23 2.23 88.4 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 50 A UNK 64 A UNK 130 A UNK 131 A UNK 132 A
UNK 272 A UNK 275 A UNK 276 A UNK 278 A UNK 279 A
UNK 282 A UNK 292 A UNK 294 A UNK 295 A UNK 297 A
UNK 298 A UNK 300 A UNK 301 A UNK 304 A UNK 328 A
UNK 336 A UNK 337 A UNK 338 A UNK 166 C UNK 167 C
UNK 271 C UNK 272 C UNK 292 C UNK 325 C UNK 326 C
UNK 327 C UNK 328 C UNK 330 C UNK 336 C UNK 337 C
UNK 338 C UNK 339 C UNK 342 C UNK 279 D UNK 318 D
UNK 319 D UNK 18 E UNK 42 E UNK 43 E UNK 65 E UNK
67 E UNK 318 F UNK 1 G UNK 2 G UNK 3 G UNK 271 G
58 3.46 3.46 89.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 171 B UNK 172 B UNK 174 B UNK 176 B UNK 177 B
UNK 207 B UNK 208 B UNK 212 B UNK 270 B UNK 272 B
UNK 273 B UNK 292 B UNK 328 B UNK 330 B UNK 336 B
UNK 337 B UNK 360 B UNK 362 B UNK 430 B UNK 432 B
UNK 292 C UNK 337 C UNK 341 C UNK 259 D UNK 260 D
UNK 263 D UNK 279 D UNK 311 D UNK 313 D UNK 314 D
UNK 318 E UNK 320 E UNK 323 E UNK 324 E UNK 327 E
UNK 356 E UNK 358 E UNK 359 E UNK 360 E UNK 314 F
UNK 316 F UNK 318 F UNK 1 G UNK 2 G UNK 3 G UNK
266 G UNK 270 G UNK 271 G UNK 274 G
59 2.14 2.14 90.1 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 128 A UNK 131 A UNK 132 A UNK 247 A UNK 251 A
UNK 252 A UNK 255 A UNK 266 A UNK 268 A UNK 271 A
UNK 272 A UNK 275 A UNK 276 A UNK 292 A UNK 294 A
UNK 298 A UNK 302 A UNK 305 A UNK 306 A UNK 308 A
UNK 309 A UNK 323 A UNK 325 A UNK 328 A UNK 336 A
UNK 337 A UNK 338 A UNK 342 A UNK 166 C UNK 167 C
UNK 271 C UNK 272 C UNK 292 C UNK 325 C UNK 326 C
UNK 327 C UNK 328 C UNK 330 C UNK 336 C UNK 337 C
UNK 338 C UNK 339 C UNK 342 C UNK 279 D UNK 318 D
UNK 319 D UNK 318 F UNK 1 G UNK 2 G UNK 3 G UNK
271 G
60 1.73 1.73 90.0 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 134 B UNK 135 B UNK 138 B UNK 139 B UNK 162 B
UNK 291 B UNK 296 B UNK 299 B UNK 309 B UNK 310 B
UNK 341 B UNK 344 B UNK 345 B UNK 346 B UNK 347 B
UNK 292 C UNK 337 C UNK 341 C UNK 259 D UNK 260 D
UNK 263 D UNK 279 D UNK 311 D UNK 313 D UNK 314 D
UNK 163 F UNK 187 F UNK 188 F UNK 189 F UNK 191 F
UNK 192 F UNK 257 F UNK 260 F UNK 263 F UNK 279 F
UNK 311 F UNK 313 F UNK 316 F UNK 318 F UNK 319 F
UNK 1 G UNK 2 G UNK 3 G UNK 270 G UNK 271 G UNK
274 G
61 2.64 2.64 91.9 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 137 B UNK 291 B UNK 296 B UNK 299 B UNK 341 B
UNK 344 B UNK 292 C UNK 337 C UNK 341 C UNK 259 D
UNK 260 D UNK 263 D UNK 279 D UNK 311 D UNK 313 D
UNK 314 D UNK 94 F UNK 102 F UNK 103 F UNK 163 F
UNK 167 F UNK 183 F UNK 187 F UNK 188 F UNK 189 F
UNK 192 F UNK 193 F UNK 196 F UNK 197 F UNK 198 F
UNK 217 F UNK 256 F UNK 257 F UNK 260 F UNK 263 F
UNK 279 F UNK 311 F UNK 313 F UNK 316 F UNK 318 F
UNK 319 F UNK 1 G UNK 2 G UNK 3 G UNK 270 G UNK
271 G UNK 274 G
62 2.68 2.68 93.5 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 291 B UNK 296 B UNK 299 B UNK 341 B UNK 344 B
UNK 292 C UNK 337 C UNK 341 C UNK 259 D UNK 260 D
UNK 263 D UNK 279 D UNK 311 D UNK 313 D UNK 314 D
UNK 163 F UNK 166 F UNK 167 F UNK 170 F UNK 174 F
UNK 175 F UNK 177 F UNK 179 F UNK 183 F UNK 187 F
UNK 188 F UNK 189 F UNK 192 F UNK 196 F UNK 200 F
UNK 205 F UNK 211 F UNK 212 F UNK 213 F UNK 214 F
UNK 215 F UNK 256 F UNK 257 F UNK 260 F UNK 263 F
UNK 279 F UNK 311 F UNK 313 F UNK 316 F UNK 318 F
UNK 319 F UNK 1 G UNK 2 G UNK 3 G UNK 270 G UNK
271 G UNK 274 G
63 2.41 2.41 99.9 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 107 B UNK 116 B UNK 117 B UNK 171 B UNK 172 B
UNK 176 B UNK 203 B UNK 204 B UNK 205 B UNK 207 B
UNK 208 B UNK 212 B UNK 213 B UNK 214 B UNK 216 B
UNK 217 B UNK 231 B UNK 269 B UNK 270 B UNK 272 B
UNK 273 B UNK 292 B UNK 328 B UNK 330 B UNK 336 B
UNK 337 B UNK 166 C UNK 167 C UNK 271 C UNK 272 C
UNK 292 C UNK 325 C UNK 326 C UNK 327 C UNK 328 C
UNK 330 C UNK 336 C UNK 338 C UNK 339 C UNK 342 C
UNK 123 E UNK 124 E UNK 126 E UNK 318 E UNK 320 E
UNK 323 E UNK 324 E UNK 327 E UNK 314 F UNK 316 F
UNK 318 F UNK 1 G UNK 266 G UNK 270 G UNK 274 G
64 2.52 2.52 101.3 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 107 B UNK 116 B UNK 117 B UNK 171 B UNK 172 B
UNK 176 B UNK 203 B UNK 204 B UNK 205 B UNK 207 B
UNK 208 B UNK 212 B UNK 213 B UNK 214 B UNK 216 B
UNK 217 B UNK 231 B UNK 269 B UNK 270 B UNK 272 B
UNK 273 B UNK 292 B UNK 328 B UNK 330 B UNK 336 B
UNK 337 B UNK 292 C UNK 337 C UNK 341 C UNK 259 D
UNK 260 D UNK 263 D UNK 279 D UNK 311 D UNK 313 D
UNK 314 D UNK 123 E UNK 124 E UNK 126 E UNK 318 E
UNK 320 E UNK 323 E UNK 324 E UNK 327 E UNK 314 F
UNK 316 F UNK 318 F UNK 1 G UNK 2 G UNK 3 G UNK
266 G UNK 270 G UNK 271 G UNK 274 G
65 2.78 2.78 15.5 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 48 G UNK 49 G UNK 51 G UNK 52 G UNK 53 G UNK
113 G UNK 125 G UNK 126 G UNK 217 G
66 1.25 1.25 25.4 -0.40 -0.80 3.4 0 0 0 0 0 0 0 0  UNK 49 G UNK 53 G UNK 54 G UNK 64 G UNK 65 G UNK
105 G UNK 217 G UNK 218 G UNK 219 G UNK 221 G UNK
222 G UNK 223 G

Residue-type_colouring
Positive Negative Neutral Aliphatic Aromatic Pro & Gly Cysteine
H,K,R D,E S,T,N,Q A,V,L,I,M F,Y,W P,G C

Acknowledgement
Tunnels were calculated by MOLE 2.0 program version 2.5.13.11.08 and visualized using Pymol 0.97rc.
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