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UniProt functional annotation for O13297 | ||
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| UniProt code: O13297. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end. {ECO:0000269|PubMed:12788946}. |
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| Catalytic activity: | |
Reaction=a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O = a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate; Xref=Rhea:RHEA:11008, Rhea:RHEA-COMP:13929, Rhea:RHEA-COMP:13942, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:138276, ChEBI:CHEBI:138288; EC=3.1.3.33; |
| Cofactor: | |
Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Divalent metal ions.; |
| Subunit: | |
The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an RNA 5'- triphosphatase. {ECO:0000269|PubMed:12788946}. |
| Subcellular location: | |
Nucleus. |
| Miscellaneous: | |
Present with 3900 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the fungal TPase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.