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UniProt functional annotation for P61823 | ||
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| UniProt code: P61823. |
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| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
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| Function: | |
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double- stranded RNA. {ECO:0000269|PubMed:7479688}. |
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| Catalytic activity: | |
Reaction=An (RNA) containing cytidine + H(2)O = an (RNA)-3'-cytidine- 3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA).; EC=4.6.1.18; |
| Catalytic activity: | |
Reaction=An (RNA) containing uridine + H(2)O = an (RNA)-3'-uridine-3'- phosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA).; EC=4.6.1.18; |
| Subunit: | |
Interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may occur. Interaction with RNH1 inhibits this protein (By similarity). Monomer. {ECO:0000250, ECO:0000269|PubMed:11513604}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Pancreas. |
| Miscellaneous: | |
Ribonuclease can destabilize or unwind the DNA helix by complexing with single-stranded DNA; this complex arises by an extended multisite cation-anion interaction between the lysine and arginine residues of the enzyme and the phosphate groups of the nucleotides. |
| Similarity: | |
Belongs to the pancreatic ribonuclease family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.