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UniProt functional annotation for P15559 | ||
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| UniProt code: P15559. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. |
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| Catalytic activity: | |
Reaction=a quinone + H(+) + NADH = a quinol + NAD(+); Xref=Rhea:RHEA:46160, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124; EC=1.6.5.2; |
| Catalytic activity: | |
Reaction=a quinone + H(+) + NADPH = a quinol + NADP(+); Xref=Rhea:RHEA:46164, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:132124; EC=1.6.5.2; |
| Cofactor: | |
Name=FAD; Xref=ChEBI:CHEBI:57692; |
| Activity regulation: | |
Inhibited by dicoumarol. |
| Subunit: | |
Homodimer (PubMed:10543876, PubMed:10706635, PubMed:11735396, PubMed:11587640, PubMed:16700548). Interacts with PDLIM4 isoform 2; this interaction stabilizes PDLIM4 isoform 2 in response to oxidative stress and protects it from ubiquitin-independent degradation by the core 20S proteasome (PubMed:21636573). {ECO:0000269|PubMed:10543876, ECO:0000269|PubMed:10706635, ECO:0000269|PubMed:11587640, ECO:0000269|PubMed:11735396, ECO:0000269|PubMed:16700548, ECO:0000269|PubMed:21636573}. |
| Subcellular location: | |
Cytoplasm. |
| Induction: | |
By dioxin (PubMed:1657151). By oxidative stress (PubMed:21636573). {ECO:0000269|PubMed:1657151, ECO:0000269|PubMed:21636573}. |
| Mass spectrometry: | |
Mass=30864; Mass_error=6; Method=Electrospray; Evidence={ECO:0000269|PubMed:11735396}; |
| Polymorphism: | |
The Ser-187 polymorphism may be linked to susceptibility to forms of cancers. |
| Miscellaneous: | |
Quinone reductase accepts electrons from both NADH and NADPH with equal efficiency. |
| Similarity: | |
Belongs to the NAD(P)H dehydrogenase (quinone) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.