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UniProt functional annotation for P04278 | ||
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| UniProt code: P04278. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. |
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| Subunit: | |
Homodimer. |
| Subcellular location: | |
Secreted {ECO:0000250}. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis. {ECO:0000250}. |
| Tissue specificity: | |
Isoform 1 and isoform 2 are present in liver and testis. |
| Ptm: | |
Variant Asn-356 contains one N-linked (GlcNAc...) at position 356. {ECO:0000269|PubMed:1400872, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218}. |
| Miscellaneous: | |
[Isoform 2]: Incomplete sequence. {ECO:0000305}. |
| Sequence caution: | |
Sequence=CAA29309.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.