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UniProt functional annotation for P50591 | ||
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| UniProt code: P50591. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. {ECO:0000269|PubMed:10549288, ECO:0000269|PubMed:26457518}. |
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| Subunit: | |
Homotrimer (PubMed:26457518). One TNFSF10 homotrimer interacts with three TNFSF10A mononers (PubMed:26457518). One TNFSF10 homotrimer interacts with three TNFSF10B mononers (PubMed:10549288). {ECO:0000269|PubMed:10549288, ECO:0000269|PubMed:26457518}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:14609566}; Single-pass type II membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:14609566}. Note=Exists both as membrane-bound and soluble form. {ECO:0000269|PubMed:14609566}. |
| Tissue specificity: | |
Widespread; most predominant in spleen, lung and prostate. |
| Ptm: | |
Tyrosine phosphorylated by PKDCC/VLK. {ECO:0000269|PubMed:25171405}. |
| Miscellaneous: | |
[Isoform 2]: Induced upon HIV infection, antagonizes signaling via TRAIL receptor R2 (TNFRSF10B). {ECO:0000305}. |
| Similarity: | |
Belongs to the tumor necrosis factor family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.