UniProt functional annotation for P69178



	UniProt functional annotation for P69178

UniProt codes: P69178, P08027.

Organism: Bacteriophage H30.

Taxonomy: Viruses; unclassified bacterial viruses.

Function: The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.

Subunit: Shiga-like toxin contains a single subunit A and five copies of subunit B. {ECO:0000269|Ref.2}.

Subcellular location: Secreted.

Domain: There are three Gb3-binding sites in each subunit B monomer, allowing for a tighter binding to the target cell. Binding sites 1 and 2 have higher binding affinities than site 3 (By similarity). {ECO:0000250}.

Similarity: Belongs to the stxB family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Bacteriophage H30.
Taxonomy:		Viruses; unclassified bacterial viruses.



Function:		The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human intestinal microvilli.


Subunit:		Shiga-like toxin contains a single subunit A and five copies of subunit B. {ECO:0000269\|Ref.2}.
Subcellular location:		Secreted.
Domain:		There are three Gb3-binding sites in each subunit B monomer, allowing for a tighter binding to the target cell. Binding sites 1 and 2 have higher binding affinities than site 3 (By similarity). {ECO:0000250}.
Similarity:		Belongs to the stxB family. {ECO:0000305}.