PDBsum entry 1cwc

Isomerase/immunosuppressant

PDB id: 1cwc

Contents

Protein chains

165 a.a. *

11 a.a. *

Waters ×169

* Residue conservation analysis

References listed in PDB file

Key reference

• Title: Improved binding affinity for cyclophilin a by a cyclosporin derivative singly modified at its effector domain.
• Authors: C.Papageorgiou, A.Florineth, V.Mikol.
• Ref.: J Med Chem, 1994, 37, 3674-3676. [DOI no: 10.1021/jm00048a002]
• PubMed id: 7966126

Abstract

No abstract given.

Secondary reference #1

• Title: Crystallization of the complex between cyclophilin a and cyclosporin derivatives: the use of cross-Seeding.
• Authors: V.Mikol, D.Duc.
• Ref.: Acta Crystallogr D Biol Crystallogr, 1994, 50, 543-549. [DOI no: 10.1107/S0907444994001800]
• PubMed id: 15299416

Figure 3.
Fig. 3. Photomicrographs of the habit of representative crystals of CypA/CsA analog complexes grown by cross-seeding. CsA/CypA (a), [N-Me-y-OH-Leu4]-CsA/CypA (b), [MeBm2tl]-CsA/CypA (c), DH-[VaI2(aSMe3)]-CsA/CypA (d). The bar in (d) represents 100 ~m.

The above figure is reproduced from the cited reference with permission from the IUCr

Secondary reference #2

• Title: The X-Ray structure of (mebm2t)1-Cyclosporin complexed with cyclophilin a provides an explanation for its anomalously high immunosuppressive activity.
• Authors: V.Mikol, J.Kallen, M.D.Walkinshaw.
• Ref.: Protein Eng, 1994, 7, 597-603.
• PubMed id: 8073029

Secondary reference #3

• Title: X-Ray structure of a monomeric cyclophilin a-Cyclosporin a crystal complex at 2.1 a resolution.
• Authors: V.Mikol, J.Kallen, G.Pflügl, M.D.Walkinshaw.
• Ref.: J Mol Biol, 1993, 234, 1119-1130.
• PubMed id: 8263916

Secondary reference #4

• Title: X-Ray structure of a decameric cyclophilin-Cyclosporin crystal complex.
• Authors: G.Pflügl, J.Kallen, T.Schirmer, J.N.Jansonius, M.G.Zurini, M.D.Walkinshaw.
• Ref.: Nature, 1993, 361, 91-94.
• PubMed id: 8421501