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UniProt functional annotation for P05091 | ||
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| UniProt code: P05091. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Catalytic activity: | |
Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.3; |
| Pathway: | |
Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. |
| Subunit: | |
Homotetramer. |
| Subcellular location: | |
Mitochondrion matrix. |
| Polymorphism: | |
Genetic variation in ALDH2 is responsible for individual differences in responses to drinking alcohol [MIM:610251]. Allele ALDH2*2 is associated with a very high incidence of acute alcohol intoxication in Orientals and South American Indians, as compared to Caucasians. {ECO:0000269|PubMed:8561277}. |
| Similarity: | |
Belongs to the aldehyde dehydrogenase family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAA62825.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAA68290.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAA68290.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.