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UniProt functional annotation for P40223 | ||
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| UniProt code: P40223. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface. |
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| Subunit: | |
Homodimer. The dimeric receptor binds two CSF3 molecules. Interacts with CEACAM1; down-regulates the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (PubMed:21029969). {ECO:0000269|PubMed:10537111, ECO:0000269|PubMed:21029969}. |
| Subcellular location: | |
Membrane; Single-pass type I membrane protein. |
| Tissue specificity: | |
Found in bone marrow. |
| Domain: | |
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. |
| Domain: | |
The box 1 motif is required for JAK interaction and/or activation. |
| Ptm: | |
N-glycosylated. {ECO:0000250|UniProtKB:Q99062}. |
| Similarity: | |
Belongs to the type I cytokine receptor family. Type 2 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.