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PDBsum entry 1cto
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Binding protein
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PDB id
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1cto
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References listed in PDB file
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Key reference
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Title
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Solution structure of an extracellular domain containing the wsxws motif of the granulocyte colony-Stimulating factor receptor and its interaction with ligand.
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Authors
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K.Yamasaki,
S.Naito,
H.Anaguchi,
T.Ohkubo,
Y.Ota.
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Ref.
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Nat Struct Biol, 1997,
4,
498-504.
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PubMed id
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Abstract
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We have determined the NMR structure of a ligand-binding domain of the
granulocyte colony-stimulating factor (G-CSF) receptor, containing the highly
conserved WSxWS motif. The domain consists of seven beta-strands with the
fibronectin type III-like topology seen in several cytokine receptors.
Comparisons between the spectra of the 15N-labelled domain with and without
G-CSF indicate that the major ligand-recognition site is on the FG loop just
upstream of the WSxWS sequence, and not on the BC loop which is mainly used in
the growth hormone system. The WSxWS residues are suggested to contribute to
ligand-recognition and to the protein architecture of the G-CSF receptor.
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Secondary reference #1
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Title
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Ligand binding characteristics of the carboxyl-Terminal domain of the cytokine receptor homologous region of the granulocyte colony-Stimulating factor receptor.
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Authors
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H.Anaguchi,
O.Hiraoka,
K.Yamasaki,
S.Naito,
Y.Ota.
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Ref.
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J Biol Chem, 1995,
270,
27845-27851.
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PubMed id
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