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UniProt functional annotation for P37300 | ||
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| UniProt code: P37300. |
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| Organism: | |
Conus magus (Magical cone). |
| Taxonomy: | |
Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda; Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus. |
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| Function: | |
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin preferentially blocks P/Q-type calcium channels (Cav2.1/CACNA1A) (IC(50)=0.60 nM) (PubMed:1352986, PubMed:10938268). Shows also an inhibition on Cav2.2/CACNA1A channels (IC(50)=7.0 nM) (PubMed:10938268). {ECO:0000269|PubMed:10938268, ECO:0000269|PubMed:1352986}. |
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| Subcellular location: | |
Secreted {ECO:0000305|PubMed:1352986}. |
| Tissue specificity: | |
Expressed by the venom duct. {ECO:0000305|PubMed:1352986}. |
| Domain: | |
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. {ECO:0000269|PubMed:10373375, ECO:0000269|PubMed:7731037}. |
| Domain: | |
The cysteine framework is VI/VII (C-C-CC-C-C). {ECO:0000305}. |
| Ptm: | |
Not hydroxylated; hydroxylation, on a synthetic hydroxylated MVIIC, has a significant impact on the oxidative folding but not on the biological activity. {ECO:0000269|PubMed:18189422}. |
| Similarity: | |
Belongs to the conotoxin O1 superfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.