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PDBsum entry 1cjh
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Unknown function
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PDB id
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1cjh
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References listed in PDB file
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Key reference
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Title
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The whey acidic protein family: a new signature motif and three-Dimensional structure by comparative modeling.
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Authors
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S.Ranganathan,
K.J.Simpson,
D.C.Shaw,
K.R.Nicholas.
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Ref.
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J Mol Graph Model, 1999,
17,
106.
[DOI no: ]
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PubMed id
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Abstract
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Whey acidic proteins (WAP) from the mouse, rat, rabbit, camel, and pig comprise
two "four-disulfide core" domains. From a detailed analysis of all sequences
containing this domain, we propose a new PROSITE motif
([KRHGVLN]-X-¿PF¿-X-[CF]-[PQSVLI]-X(9,19)-C-¿P¿-X-[DN]-X-¿N¿
-[CE]-X(5)-C-C) to accurately identify new four-disulfide core proteins. A
consensus model for the WAP proteins is proposed, based on the human mucous
proteinase inhibitor crystal structure. This article presents a detailed atomic
model for the two-domain porcine WAP sequence by comparative modeling. Surface
electrostatic potential calculations indicate that the second domain of the pig
WAP model is similar to the functional human mucous proteinase inhibitor
domains, whereas the first domain may be nonfunctional.
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Secondary reference #1
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Title
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Molecular characterisation and hormone-Dependent expression of the porcine whey acidic protein gene.
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Authors
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K.J.Simpson,
P.Bird,
D.Shaw,
K.Nicholas.
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Ref.
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J Mol Endocrinol, 1998,
20,
27-35.
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PubMed id
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Secondary reference #2
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Title
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The 2.5 a X-Ray crystal structure of the acid-Stable proteinase inhibitor from human mucous secretions analysed in its complex with bovine alpha-Chymotrypsin.
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Authors
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M.G.Grütter,
G.Fendrich,
R.Huber,
W.Bode.
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Ref.
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Embo J, 1988,
7,
345-351.
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PubMed id
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