|
|
||
|
|
|
|
|
UniProt functional annotation for P00044 | ||
|
|
|
|
|
|
||
| UniProt code: P00044. |
|
||
| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
|
||
|
||
| Function: | |
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of ubiquinol-cytochrome c oxidoreductase. Cytochrome c then transfers this electron to the dinuclear copper A center (CU(A)) of the COX2 subunit of cytochrome oxidase, the final protein carrier in the mitochondrial electron-transport chain. Isoform 1 (CYC1) is the predominant cytochrome c during aerobic/normoxic growth. {ECO:0000269|PubMed:7814361, ECO:0000269|PubMed:7851399, ECO:0000269|PubMed:9169434}. |
|
||
| Cofactor: | |
Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000269|PubMed:18390544}; Note=Binds 1 heme group covalently per subunit. {ECO:0000269|PubMed:18390544}; |
| Subcellular location: | |
Mitochondrion intermembrane space {ECO:0000269|PubMed:22984289, ECO:0000269|PubMed:9866716}. |
| Induction: | |
By oxygen at the level of transcription. Expression drops rapidly when the oxygen concentration falls below 0.5 uM O(2). {ECO:0000269|PubMed:9169434}. |
| Ptm: | |
Methylation may enhance its transport into mitochondria. Methylation occurs in fungi, plants, and some protozoa, but not in animals. The precise role of methylation at Lys-79 is unknown, but it seems to preclude pro-apoptotic activity, possibly by lowering affinity for APAF1. {ECO:0000269|PubMed:10791961, ECO:0000269|PubMed:10821864, ECO:0000269|PubMed:18390544, ECO:0000269|PubMed:2822698}. |
| Miscellaneous: | |
Present with 7330 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the cytochrome c family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.