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UniProt functional annotation for P24817 | ||
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| UniProt code: P24817. |
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| Organism: | |
Momordica charantia (Bitter gourd) (Balsam pear). |
| Taxonomy: | |
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Momordiceae; Momordica. |
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| Function: | |
Irreversibly relaxes supercoiled DNA and catalyzes double- stranded breakage. Acts also as a ribosome inactivating protein. |
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| Catalytic activity: | |
Reaction=Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.; EC=3.2.2.22; |
| Ptm: | |
Bound to a branched hexasaccharide. |
| Miscellaneous: | |
Possesses anti-HIV and antitumoral activities. Inhibits HIV-1 integrase. |
| Miscellaneous: | |
Manganese or zinc required for enhancing substrate binding rather than catalysis. |
| Miscellaneous: | |
The oligosaccharide does not influence the fold of the polypeptide chain and probably does not play a role in the enzymatic function. |
| Miscellaneous: | |
Is not toxic to uninfected normal cells as it cannot enter into them. |
| Similarity: | |
Belongs to the ribosome-inactivating protein family. Type 1 RIP subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.