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UniProt functional annotation for P01452 | ||
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| UniProt code: P01452. |
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| Organism: | |
Naja mossambica (Mozambique spitting cobra). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Naja. |
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| Function: | |
Shows cytolytic activity on many different cells by forming pore in lipid membranes. In vivo, increases heart rate or kills the animal by cardiac arrest. In addition, it binds to heparin with high affinity, interacts with Kv channel-interacting protein 1 (KCNIP1) in a calcium-independent manner, and binds to integrin alpha-V/beta-3 (ITGAV/ITGB3) with moderate affinity. {ECO:0000250|UniProtKB:P60301, ECO:0000250|UniProtKB:P60304, ECO:0000269|PubMed:8182052}. |
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| Subunit: | |
Monomer in solution; Homodimer and oligomer in the presence of negatively charged lipids forming a pore with a size ranging between 20 and 30 Angstroms. {ECO:0000250|UniProtKB:P60301}. |
| Subcellular location: | |
Secreted {ECO:0000269|PubMed:4834686}. Target cell membrane {ECO:0000250|UniProtKB:P60301}. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Toxic dose: | |
LD(50) is 1.97 mg/kg by intravenous injection. |
| Miscellaneous: | |
Is classified as a S-type cytotoxin, since a serine residue stands at position 28 (Ser-29 in standard classification). {ECO:0000305|PubMed:8182052}. |
| Similarity: | |
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type IA cytotoxin sub-subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.