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PDBsum entry 1cdf
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References listed in PDB file
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Key reference
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Title
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Construction and analysis of a detailed three-Dimensional model of the ligand binding domain of the human b cell receptor cd40.
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Authors
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J.Bajorath,
A.Aruffo.
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Ref.
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Proteins, 1997,
27,
59-70.
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PubMed id
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Abstract
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The interaction between the human B cell receptor CD40 and its ligand on T cells
is critical for B cell proliferation and the regulation of humoral immune
responses. CD40 is a member of the tumor necrosis factor receptor (TNFR) family.
We report here the construction and analysis of a detailed three-dimensional
model of the TNFR-homologous extracellular region of CD40. This study provides
an example for structure-based model building in the presence of low sequence
similarity. The assessment of model quality and sequence-structure compatibility
is emphasized, and limitations of the model are discussed. The current CD40
model predicts structural details beyond the backbone level. Features of the
CD40 ligand binding site are discussed in conjunction with the results of a
previous mutagenesis study.
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Secondary reference #1
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Title
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Analysis of gp39/cd40 interactions using molecular models and site-Directed mutagenesis.
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Authors
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J.Bajorath,
J.S.Marken,
N.J.Chalupny,
T.L.Spoon,
A.W.Siadak,
M.Gordon,
R.J.Noelle,
D.Hollenbaugh,
A.Aruffo.
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Ref.
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Biochemistry, 1995,
34,
9884-9892.
[DOI no: ]
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PubMed id
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