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PDBsum entry 1cda
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References listed in PDB file
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Key reference
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Title
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A 3-D model for the cd40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors.
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Authors
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M.C.Peitsch,
C.V.Jongeneel.
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Ref.
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Int Immunol, 1993,
5,
233-238.
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PubMed id
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Abstract
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Based on the similarity in primary structure between the newly characterized
ligand for CD40 (CD40L) and the tumor necrosis factors (TNFs), we have modeled a
detailed 3-D structure for CD40L. We used the known structure of TNF alpha as a
template for the generation of the CD40L model. The soundness of the
model-building algorithms was verified by constructing a 3-D model of TNF beta
and comparing it to its crystallographically determined structure. The CD40L
sequence is entirely compatible with the 'jelly-roll' beta-strand structure
characteristic of the TNFs. Like the TNFs, CD40L is predicted to form a compact
trimer, although the interactions between monomers are distinct from those found
in the TNFs. The model predicts which regions of CD40L could interact with its
receptor(s) and which amino acids are essential for the maintenance of its
trimeric structure.
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Secondary reference #1
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Title
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Molecular and biological characterization of a murine ligand for cd40.
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Authors
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R.J.Armitage,
W.C.Fanslow,
L.Strockbine,
T.A.Sato,
K.N.Clifford,
B.M.Macduff,
D.M.Anderson,
S.D.Gimpel,
T.Davis-Smith,
C.R.Maliszewski.
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Ref.
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Nature, 1992,
357,
80-82.
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PubMed id
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Secondary reference #2
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Title
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The structure of human lymphotoxin (tumor necrosis factor-Beta) at 1.9-A resolution.
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Authors
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M.J.Eck,
M.Ultsch,
E.Rinderknecht,
A.M.De vos,
S.R.Sprang.
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Ref.
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J Biol Chem, 1992,
267,
2119-2122.
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PubMed id
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Secondary reference #3
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Title
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The structure of tumor necrosis factor-Alpha at 2.6 a resolution. Implications for receptor binding.
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Authors
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M.J.Eck,
S.R.Sprang.
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Ref.
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J Biol Chem, 1989,
264,
17595-17605.
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PubMed id
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