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UniProt functional annotation for P0DUB6 | ||
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| UniProt code: P0DUB6. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Calcium-binding enzyme that initiates starch digestion in the oral cavity (PubMed:12527308). Catalyzes the hydrolysis of internal (1->4)-alpha-D-glucosidic bonds, yielding a mixture of maltose, isomaltose, small amounts of glucose as well as small linear and branched oligosaccharides called dextrins (PubMed:12527308). {ECO:0000269|PubMed:12527308}. |
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| Catalytic activity: | |
Reaction=Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D- glucose units.; EC=3.2.1.1; Evidence={ECO:0000269|PubMed:12527308}; |
| Cofactor: | |
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:12527308, ECO:0000269|PubMed:15299664}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000269|PubMed:12527308, ECO:0000269|PubMed:15299664}; |
| Cofactor: | |
Name=chloride; Xref=ChEBI:CHEBI:17996; Evidence={ECO:0000269|PubMed:12527308, ECO:0000269|PubMed:15299664}; Note=Binds 1 Cl(-) ion per subunit. {ECO:0000269|PubMed:12527308, ECO:0000269|PubMed:15299664}; |
| Subunit: | |
Monomer. |
| Subcellular location: | |
Secreted {ECO:0000305}. |
| Similarity: | |
Belongs to the glycosyl hydrolase 13 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.