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UniProt functional annotation for P55928 | ||
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| UniProt code: P55928. |
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| Organism: | |
Pandinus imperator (Emperor scorpion). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Scorpiones; Iurida; Scorpionoidea; Scorpionidae; Scorpioninae; Pandinus. |
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| Function: | |
Potent inhibitor of the A-type voltage-gated potassium channels. Most potent inhibitor of Kv1.2/KCNA2 channels. Reversibly block the Shaker B potassium-channels (Kv1.1 sub-family), but with a lower affinity than PiTX-K alpha. {ECO:0000269|PubMed:8660410}. |
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| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Domain: | |
Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta). |
| Similarity: | |
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 07 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.