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UniProt functional annotation for P05326 | ||
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| UniProt code: P05326. |
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| Organism: | |
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus; Aspergillus subgen. Nidulantes. |
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| Function: | |
Removes, in the presence of oxygen, 4 hydrogen atoms from delta-L-(alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV) to form the azetidinone and thiazolidine rings of isopenicillin. |
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| Catalytic activity: | |
Reaction=N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = 2 H2O + isopenicillin N; Xref=Rhea:RHEA:22428, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:58399, ChEBI:CHEBI:58572; EC=1.21.3.1; |
| Cofactor: | |
Name=Fe cation; Xref=ChEBI:CHEBI:24875; |
| Cofactor: | |
Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; |
| Pathway: | |
Antibiotic biosynthesis; penicillin G biosynthesis; penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 2/3. |
| Similarity: | |
Belongs to the iron/ascorbate-dependent oxidoreductase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.