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UniProt functional annotation for P81658 | ||
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| UniProt code: P81658. |
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| Organism: | |
Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Dendroaspis. |
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| Function: | |
Potent blocker of high-voltage-activated calcium ion channels in the nanomolar range, particularly the L-type channels in cerebellar granule cells. The sensitivity of L-, N- and P-type channels to CAC is tissue and species-dependent. Blocks the L-type current of cardiac cells, depressing cardiac contractility. |
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| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Similarity: | |
Belongs to the venom Kunitz-type family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.