UniProt functional annotation for P00157



	UniProt functional annotation for P00157

UniProt code: P00157.

Organism: Bos taurus (Bovine).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.

Function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. {ECO:0000269|PubMed:1327781, ECO:0000269|PubMed:20025846, ECO:0000269|PubMed:9485330, ECO:0000305|PubMed:189810}.

Cofactor: Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000269|PubMed:12269811, ECO:0000269|PubMed:15312779, ECO:0000269|PubMed:16024040, ECO:0000269|PubMed:16924113, ECO:0000269|PubMed:9204897, ECO:0000269|PubMed:9651245}; Note=Binds 2 heme groups non-covalently. {ECO:0000269|PubMed:12269811, ECO:0000269|PubMed:15312779, ECO:0000269|PubMed:16024040, ECO:0000269|PubMed:16924113, ECO:0000269|PubMed:9204897, ECO:0000269|PubMed:9651245};

Subunit: The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer. {ECO:0000269|PubMed:12269811, ECO:0000269|PubMed:15312779, ECO:0000269|PubMed:16024040, ECO:0000269|PubMed:16924113, ECO:0000269|PubMed:9204897, ECO:0000269|PubMed:9651245, ECO:0000305|PubMed:189810}.

Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:1225597, ECO:0000305|PubMed:1327781, ECO:0000305|PubMed:189810}; Multi-pass membrane protein {ECO:0000269|PubMed:12269811, ECO:0000269|PubMed:15312779, ECO:0000269|PubMed:16024040, ECO:0000269|PubMed:16924113, ECO:0000269|PubMed:9204897, ECO:0000269|PubMed:9651245}.

Tissue specificity: Detected in heart (at protein level). {ECO:0000269|PubMed:1225597, ECO:0000269|PubMed:1327781, ECO:0000269|PubMed:189810}.

Miscellaneous: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.

Similarity: Belongs to the cytochrome b family. {ECO:0000255|PROSITE- ProRule:PRU00967, ECO:0000255|PROSITE-ProRule:PRU00968}.

Annotations taken from UniProtKB at the EBI.


Organism:		Bos taurus (Bovine).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.



Function:		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. {ECO:0000269\|PubMed:1327781, ECO:0000269\|PubMed:20025846, ECO:0000269\|PubMed:9485330, ECO:0000305\|PubMed:189810}.


Cofactor:		Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000269\|PubMed:12269811, ECO:0000269\|PubMed:15312779, ECO:0000269\|PubMed:16024040, ECO:0000269\|PubMed:16924113, ECO:0000269\|PubMed:9204897, ECO:0000269\|PubMed:9651245}; Note=Binds 2 heme groups non-covalently. {ECO:0000269\|PubMed:12269811, ECO:0000269\|PubMed:15312779, ECO:0000269\|PubMed:16024040, ECO:0000269\|PubMed:16924113, ECO:0000269\|PubMed:9204897, ECO:0000269\|PubMed:9651245};
Subunit:		The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer. {ECO:0000269\|PubMed:12269811, ECO:0000269\|PubMed:15312779, ECO:0000269\|PubMed:16024040, ECO:0000269\|PubMed:16924113, ECO:0000269\|PubMed:9204897, ECO:0000269\|PubMed:9651245, ECO:0000305\|PubMed:189810}.
Subcellular location:		Mitochondrion inner membrane {ECO:0000269\|PubMed:1225597, ECO:0000305\|PubMed:1327781, ECO:0000305\|PubMed:189810}; Multi-pass membrane protein {ECO:0000269\|PubMed:12269811, ECO:0000269\|PubMed:15312779, ECO:0000269\|PubMed:16024040, ECO:0000269\|PubMed:16924113, ECO:0000269\|PubMed:9204897, ECO:0000269\|PubMed:9651245}.
Tissue specificity:		Detected in heart (at protein level). {ECO:0000269\|PubMed:1225597, ECO:0000269\|PubMed:1327781, ECO:0000269\|PubMed:189810}.
Miscellaneous:		Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
Similarity:		Belongs to the cytochrome b family. {ECO:0000255\|PROSITE- ProRule:PRU00967, ECO:0000255\|PROSITE-ProRule:PRU00968}.