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UniProt functional annotation for P56637 | ||
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| UniProt code: P56637. |
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| Organism: | |
Hottentotta judaicus (Black scorpion) (Buthotus judaicus). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Scorpiones; Buthida; Buthoidea; Buthidae; Hottentotta. |
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| Function: | |
Excitatory insect toxins induce a spastic paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active only on insects. |
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| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Domain: | |
Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta). {ECO:0000305}. |
| Mass spectrometry: | |
Mass=8455; Method=Unknown; Evidence={ECO:0000269|PubMed:10026198}; |
| Toxic dose: | |
Both variants Bjxtr-IT.56E and Bjxtr-IT.56K have an PD(50) of 9.6 ng/100 mg of body weight of blowfly larvae. {ECO:0000269|PubMed:10026198}. |
| Similarity: | |
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.