UniProt functional annotation for P18946



	UniProt functional annotation for P18946

UniProt code: P18946.

Organism: Gallus gallus (Chicken).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus.

Function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. {ECO:0000250|UniProtKB:P00157}.

Cofactor: Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000269|PubMed:20025846, ECO:0000269|PubMed:21575592, ECO:0000269|PubMed:22690928, ECO:0000269|PubMed:9565029}; Note=Binds 2 heme groups non-covalently. {ECO:0000269|PubMed:20025846, ECO:0000269|PubMed:21575592, ECO:0000269|PubMed:22690928, ECO:0000269|PubMed:9565029};

Subunit: The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer. {ECO:0000269|PubMed:20025846, ECO:0000269|PubMed:21575592, ECO:0000269|PubMed:22690928, ECO:0000269|PubMed:9565029}.

Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00157}; Multi-pass membrane protein {ECO:0000269|PubMed:20025846, ECO:0000269|PubMed:21575592, ECO:0000269|PubMed:22690928, ECO:0000269|PubMed:9565029}.

Miscellaneous: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm. {ECO:0000250}.

Similarity: Belongs to the cytochrome b family. {ECO:0000255|PROSITE- ProRule:PRU00967, ECO:0000255|PROSITE-ProRule:PRU00968}.

Annotations taken from UniProtKB at the EBI.


Organism:		Gallus gallus (Chicken).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus.



Function:		Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. {ECO:0000250\|UniProtKB:P00157}.


Cofactor:		Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000269\|PubMed:20025846, ECO:0000269\|PubMed:21575592, ECO:0000269\|PubMed:22690928, ECO:0000269\|PubMed:9565029}; Note=Binds 2 heme groups non-covalently. {ECO:0000269\|PubMed:20025846, ECO:0000269\|PubMed:21575592, ECO:0000269\|PubMed:22690928, ECO:0000269\|PubMed:9565029};
Subunit:		The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer. {ECO:0000269\|PubMed:20025846, ECO:0000269\|PubMed:21575592, ECO:0000269\|PubMed:22690928, ECO:0000269\|PubMed:9565029}.
Subcellular location:		Mitochondrion inner membrane {ECO:0000250\|UniProtKB:P00157}; Multi-pass membrane protein {ECO:0000269\|PubMed:20025846, ECO:0000269\|PubMed:21575592, ECO:0000269\|PubMed:22690928, ECO:0000269\|PubMed:9565029}.
Miscellaneous:		Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm. {ECO:0000250}.
Similarity:		Belongs to the cytochrome b family. {ECO:0000255\|PROSITE- ProRule:PRU00967, ECO:0000255\|PROSITE-ProRule:PRU00968}.