UniProt functional annotation for Q15438



	UniProt functional annotation for Q15438

UniProt code: Q15438.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. {ECO:0000250|UniProtKB:Q9QX11, ECO:0000269|PubMed:10652308, ECO:0000269|PubMed:29420262, ECO:0000269|PubMed:9653114}.

Subunit: Interacts with TRIM23 and CYTIP (PubMed:10748148, PubMed:11867758). Interacts (via coiled-coil domain) with FRMD4A (via coiled-coil domain) (By similarity). Interacts with FRMD4B (By similarity). Found in a complex with PARD3, CYTH1 and FRMD4A (By similarity). Interacts (via N-terminal domain) with INAVA (via N- terminal domain) (PubMed:29420262). {ECO:0000250|UniProtKB:Q9QX11, ECO:0000269|PubMed:10748148, ECO:0000269|PubMed:11867758, ECO:0000269|PubMed:29420262}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:17398095}; Peripheral membrane protein {ECO:0000269|PubMed:17398095}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9QX11}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9QX11}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9QX11}. Note=Colocalized with TJP1 during epithelial polarization. {ECO:0000250|UniProtKB:Q9QX11}.

Tissue specificity: Ubiquitous.

Domain: Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate. {ECO:0000250}.

Domain: Autoinhibited by its C-terminal basic region. {ECO:0000250|UniProtKB:Q9QX11}.

Ptm: Ubiquitinated by SCF(FBXW11) E3 ubiquitin-protein ligase complex. Ubiquitination induces proteasomal degradation. {ECO:0000269|PubMed:29420262}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. {ECO:0000250\|UniProtKB:Q9QX11, ECO:0000269\|PubMed:10652308, ECO:0000269\|PubMed:29420262, ECO:0000269\|PubMed:9653114}.


Subunit:		Interacts with TRIM23 and CYTIP (PubMed:10748148, PubMed:11867758). Interacts (via coiled-coil domain) with FRMD4A (via coiled-coil domain) (By similarity). Interacts with FRMD4B (By similarity). Found in a complex with PARD3, CYTH1 and FRMD4A (By similarity). Interacts (via N-terminal domain) with INAVA (via N- terminal domain) (PubMed:29420262). {ECO:0000250\|UniProtKB:Q9QX11, ECO:0000269\|PubMed:10748148, ECO:0000269\|PubMed:11867758, ECO:0000269\|PubMed:29420262}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:17398095}; Peripheral membrane protein {ECO:0000269\|PubMed:17398095}. Cytoplasm, cytosol {ECO:0000250\|UniProtKB:Q9QX11}. Cell junction, tight junction {ECO:0000250\|UniProtKB:Q9QX11}. Cell junction, adherens junction {ECO:0000250\|UniProtKB:Q9QX11}. Note=Colocalized with TJP1 during epithelial polarization. {ECO:0000250\|UniProtKB:Q9QX11}.
Tissue specificity:		Ubiquitous.
Domain:		Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate. {ECO:0000250}.
Domain:		Autoinhibited by its C-terminal basic region. {ECO:0000250\|UniProtKB:Q9QX11}.
Ptm:		Ubiquitinated by SCF(FBXW11) E3 ubiquitin-protein ligase complex. Ubiquitination induces proteasomal degradation. {ECO:0000269\|PubMed:29420262}.