UniProt functional annotation for P11916

UniProt code: P11916.

Organism:		Lithobates catesbeianus (American bullfrog) (Rana catesbeiana).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
Function:		Preferentially cleaves single-stranded RNA at pyrimidine residues with a 3'flanking guanine. Hydrolyzes poly(U) and poly(C) as substrates, and prefers the former. The S-lectins in frog eggs may be involved in the fertilization and development of the frog embryo. This lectin agglutinates various animal cells, including normal lymphocytes, erythrocytes, and fibroblasts of animal and human origin. It is cytotoxic against several tumor cells.
Subunit:		Monomer.
Subcellular location:		Secreted.
Similarity:		Belongs to the pancreatic ribonuclease family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.