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PDBsum entry 1bbt
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Contents |
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186 a.a.
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210 a.a.
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220 a.a.
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46 a.a.
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* Residue conservation analysis
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PDB id:
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Virus
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Title:
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Methods used in the structure determination of foot and mouth disease virus
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Structure:
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Foot-and-mouth disease virus (subunit vp1). Chain: 1. Engineered: yes. Foot-and-mouth disease virus (subunit vp2). Chain: 2. Engineered: yes. Foot-and-mouth disease virus (subunit vp3). Chain: 3. Engineered: yes.
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Source:
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Foot-and-mouth disease virus. Organism_taxid: 12110. Strain: bfs, 1860. Strain: bfs, 1860
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Resolution:
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Authors:
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K.R.Acharya,E.E.Fry,D.T.Logan,D.I.Stuart
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Key ref:
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E.Fry
et al.
(1993).
Methods used in the structure determination of foot-and-mouth disease virus.
Acta Crystallogr A,
49,
45-55.
PubMed id:
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Date:
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18-May-92
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Release date:
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31-Jan-94
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PROCHECK
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Headers
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References
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Q84771
(Q84771_FMDVO) -
Genome polyprotein (Fragment) from Foot-and-mouth disease virus (isolate Bovine/Germany/O1Kaufbeuren/1966 serotype O)
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Seq:
Struc:
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720 a.a.
186 a.a.*
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Q84771
(Q84771_FMDVO) -
Genome polyprotein (Fragment) from Foot-and-mouth disease virus (isolate Bovine/Germany/O1Kaufbeuren/1966 serotype O)
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Seq:
Struc:
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720 a.a.
210 a.a.*
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Enzyme class:
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Chains 1, 2, 3, 4:
E.C.?
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Acta Crystallogr A
49:45-55
(1993)
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PubMed id:
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Methods used in the structure determination of foot-and-mouth disease virus.
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E.Fry,
R.Acharya,
D.Stuart.
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ABSTRACT
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The structure of foot-and-mouth disease virus (FMDV) strain O1 BFS 1860 has been
determined to 2.9 A resolution using the molecular-replacement method [Acharya,
Fry, Stuart, Fox, Rowlands & Brown (1989). Nature (London), 337, 709-716].
Crystals of the virus with average dimensions 0.12 x 0.06 x 0.12 mm belong to
space group I23, a = 345 A with 1/12 of the icosahedral particle per asymmetric
unit giving fivefold noncrystallographic redundancy. Oscillation diffraction
photographs were collected at the SERC Synchrotron Radiation Source at Daresbury
in accordance with strict disease security regulations. The ambiguity in
particle orientation was resolved using a self-rotation function and starting
estimates of the phases to 8 A were derived from the known structures of two
picornaviruses similarly oriented in the I23 unit cell. The phases were refined
and extended using iterative averaging and solvent flattening with the
implementation of a simple automatic envelope-determination procedure to
increase the phasing power available.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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A.Janner
(2011).
Form, symmetry and packing of biomacromolecules. III. Antigenic, receptor and contact binding sites in picornaviruses.
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Acta Crystallogr A,
67,
174-189.
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S.Grudinin,
and
S.Redon
(2010).
Practical modeling of molecular systems with symmetries.
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J Comput Chem,
31,
1799-1814.
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E.E.Fry,
N.J.Knowles,
J.W.Newman,
G.Wilsden,
Z.Rao,
A.M.King,
and
D.I.Stuart
(2003).
Crystal structure of Swine vesicular disease virus and implications for host adaptation.
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J Virol,
77,
5475-5486.
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PDB code:
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S.Curry,
E.Fry,
W.Blakemore,
R.Abu-Ghazaleh,
T.Jackson,
A.King,
S.Lea,
J.Newman,
and
D.Stuart
(1997).
Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilization: the structure of empty capsids of foot-and-mouth disease virus.
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J Virol,
71,
9743-9752.
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S.Curry,
E.Fry,
W.Blakemore,
R.Abu-Ghazaleh,
T.Jackson,
A.King,
S.Lea,
J.Newman,
D.Rowlands,
and
D.Stuart
(1996).
Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and antigenicity.
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Structure,
4,
135-145.
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S.Lea,
J.Hernández,
W.Blakemore,
E.Brocchi,
S.Curry,
E.Domingo,
E.Fry,
R.Abu-Ghazaleh,
A.King,
and
J.Newman
(1994).
The structure and antigenicity of a type C foot-and-mouth disease virus.
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Structure,
2,
123-139.
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PDB code:
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
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