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UniProt functional annotation for P22576 | ||
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| UniProt code: P22576. |
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| Organism: | |
Saimiriine herpesvirus 2 (strain 488) (SaHV-2) (Herpesvirus saimiri). |
| Taxonomy: | |
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus. |
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| Function: | |
Acts synergistically with Tip to stimulate NF-kappa-B activity and interleukin-2 gene expression by binding to host TRAF proteins. Activation of NF-kappa-B protects lymphocytes from apoptosis, thereby facilitating viral induced cell transformation. {ECO:0000269|PubMed:11145913}. |
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| Subunit: | |
Binds to host RAS and TRAF2. |
| Subcellular location: | |
Host membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
| Miscellaneous: | |
Saimiriine herpesvirus 2 transforms T-lymphocytes, including human, to continuous growth in vitro. Two viral proteins, Tip and StpC, are essential for this function. The virus induced transforming activation is used as an important tool of T-cell biology, including HIV replication. |
Annotations taken from UniProtKB at the EBI.