UniProt functional annotation for O08839



	UniProt functional annotation for O08839

UniProt code: O08839.

Organism: Rattus norvegicus (Rat).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.

Function: Is a key player in the control of plasma membrane curvature, and membrane shaping and remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (By similarity). Is a negative regulator of endocytosis (PubMed:9736607, PubMed:27760323). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (By similarity). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (PubMed:27760323). May be involved in the regulation of MYC activity and the control cell proliferation (By similarity). {ECO:0000250|UniProtKB:O00499, ECO:0000250|UniProtKB:O08539, ECO:0000269|PubMed:27760323, ECO:0000269|PubMed:9736607}.

Subunit: Heterodimer with AMPH (PubMed:9348539, PubMed:9341169). Binds SH3GLB1 (By similarity). Interacts (via SH3 domain) with DNM1 (PubMed:9736607, PubMed:9341169). Interacts with SYNJ1 (PubMed:9341169). Interacts (via SH3 domain) with DNM2 (By similarity). Interacts with CLTC (By similarity). Interacts with AP2A2 (PubMed:10430869, PubMed:10380931). Interacts with AP2B1 (PubMed:16516836). Interacts with MYC (via N-terminal transactivation domain); the interaction requires the integrity of the conserved MYC box regions 1 and 2 (By similarity). Interacts with BIN2 (By similarity). Interacts with SNX4 (By similarity). Interacts (via BAR domain) with BACE1 (By similarity). Binds (via BAR domain) F-actin (By similarity). {ECO:0000250|UniProtKB:O00499, ECO:0000250|UniProtKB:O08539, ECO:0000269|PubMed:10380931, ECO:0000269|PubMed:10430869, ECO:0000269|PubMed:16516836, ECO:0000269|PubMed:9341169, ECO:0000269|PubMed:9348539, ECO:0000269|PubMed:9736607}.

Subcellular location: Nucleus {ECO:0000250|UniProtKB:O08539}. Cytoplasm {ECO:0000250|UniProtKB:O08539}. Endosome {ECO:0000250|UniProtKB:O08539}. Cell membrane, sarcolemma, T-tubule {ECO:0000269|PubMed:9182667}.

Tissue specificity: Highly expressed in the brain and muscle. Isoform AMPH2-1 is expressed only in the brain where it is concentrated in axon initial segments and nodes of Ranvier. Isoform AMPH2-2 is widely expressed. {ECO:0000269|PubMed:9182667}.

Ptm: Phosphorylated by protein kinase C.

Annotations taken from UniProtKB at the EBI.


Organism:		Rattus norvegicus (Rat).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.



Function:		Is a key player in the control of plasma membrane curvature, and membrane shaping and remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (By similarity). Is a negative regulator of endocytosis (PubMed:9736607, PubMed:27760323). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (By similarity). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (PubMed:27760323). May be involved in the regulation of MYC activity and the control cell proliferation (By similarity). {ECO:0000250\|UniProtKB:O00499, ECO:0000250\|UniProtKB:O08539, ECO:0000269\|PubMed:27760323, ECO:0000269\|PubMed:9736607}.


Subunit:		Heterodimer with AMPH (PubMed:9348539, PubMed:9341169). Binds SH3GLB1 (By similarity). Interacts (via SH3 domain) with DNM1 (PubMed:9736607, PubMed:9341169). Interacts with SYNJ1 (PubMed:9341169). Interacts (via SH3 domain) with DNM2 (By similarity). Interacts with CLTC (By similarity). Interacts with AP2A2 (PubMed:10430869, PubMed:10380931). Interacts with AP2B1 (PubMed:16516836). Interacts with MYC (via N-terminal transactivation domain); the interaction requires the integrity of the conserved MYC box regions 1 and 2 (By similarity). Interacts with BIN2 (By similarity). Interacts with SNX4 (By similarity). Interacts (via BAR domain) with BACE1 (By similarity). Binds (via BAR domain) F-actin (By similarity). {ECO:0000250\|UniProtKB:O00499, ECO:0000250\|UniProtKB:O08539, ECO:0000269\|PubMed:10380931, ECO:0000269\|PubMed:10430869, ECO:0000269\|PubMed:16516836, ECO:0000269\|PubMed:9341169, ECO:0000269\|PubMed:9348539, ECO:0000269\|PubMed:9736607}.
Subcellular location:		Nucleus {ECO:0000250\|UniProtKB:O08539}. Cytoplasm {ECO:0000250\|UniProtKB:O08539}. Endosome {ECO:0000250\|UniProtKB:O08539}. Cell membrane, sarcolemma, T-tubule {ECO:0000269\|PubMed:9182667}.
Tissue specificity:		Highly expressed in the brain and muscle. Isoform AMPH2-1 is expressed only in the brain where it is concentrated in axon initial segments and nodes of Ranvier. Isoform AMPH2-2 is widely expressed. {ECO:0000269\|PubMed:9182667}.
Ptm:		Phosphorylated by protein kinase C.