UniProt functional annotation for P34130



	UniProt functional annotation for P34130

UniProt code: P34130.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Target-derived survival factor for peripheral sensory sympathetic neurons.

Subcellular location: Secreted.

Tissue specificity: Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.

Disease: Glaucoma 1, open angle, O (GLC1O) [MIM:613100]: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. {ECO:0000269|PubMed:19765683, ECO:0000269|PubMed:20215012}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.

Similarity: Belongs to the NGF-beta family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Target-derived survival factor for peripheral sensory sympathetic neurons.


Subcellular location:		Secreted.
Tissue specificity:		Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.
Disease:		Glaucoma 1, open angle, O (GLC1O) [MIM:613100]: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. {ECO:0000269\|PubMed:19765683, ECO:0000269\|PubMed:20215012}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.
Similarity:		Belongs to the NGF-beta family. {ECO:0000305}.