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PDBsum entry 1b98
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Hormone/growth factor
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PDB id
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1b98
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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The structures of the neurotrophin 4 homodimer and the brain-Derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common trk-Binding site.
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Authors
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R.C.Robinson,
C.Radziejewski,
G.Spraggon,
J.Greenwald,
M.R.Kostura,
L.D.Burtnick,
D.I.Stuart,
S.Choe,
E.Y.Jones.
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Ref.
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Protein Sci, 1999,
8,
2589-2597.
[DOI no: ]
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PubMed id
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Abstract
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The neurotrophins are growth factors that are involved in the development and
survival of neurons. Neurotrophin release by a target tissue results in neuron
growth along the neurotrophin concentration gradient, culminating in the
eventual innervation of the target tissue. These activities are mediated through
trk cell surface receptors. We have determined the structures of the heterodimer
formed between brain-derived neurotrophic factor (BDNF) and neurotrophin 4
(NT4), as well as the structure of homodimer of NT4. We also present the
structure of the Neurotrophin 3 homodimer, which is refined to higher resolution
than previously published. These structures provide the first views of the
architecture of the NT4 protomer. Comparison of the surface of a model of the
BDNF homodimer with the structures of the neurotrophin homodimers reveals common
features that may be important in the binding between the neurotrophins and
their receptors. In particular, there exists an analogous region on the surface
of each neurotrophin that is likely to be involved in trk receptor binding.
Variations in sequence on the periphery of this common region serve to confer
trk receptor specificity.
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Secondary reference #1
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Title
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Structure of the brain-Derived neurotrophic factor/neurotrophin 3 heterodimer.
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Authors
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R.C.Robinson,
C.Radziejewski,
D.I.Stuart,
E.Y.Jones.
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Ref.
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Biochemistry, 1995,
34,
4139-4146.
[DOI no: ]
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PubMed id
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Secondary reference #2
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Title
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Heterodimers of the neurotrophic factors: formation, Isolation, And differential stability.
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Authors
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C.Radziejewski,
R.C.Robinson.
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Ref.
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Biochemistry, 1993,
32,
13350-13356.
[DOI no: ]
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PubMed id
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