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UniProt functional annotation for P0A2X8 | ||
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| UniProt code: P0A2X8. |
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| Organism: | |
Enterococcus faecium (Streptococcus faecium). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae; Enterococcus. |
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| Function: | |
Catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP. Can also catalyze, although with low efficiency, the phosphorylation of bicarbonate, leading to the formation of carboxyphosphate, an unstable intermediate found in the reactions catalyzed by carbamoyl-phosphate synthase and biotin carboxylase. Can also use acetate. |
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| Catalytic activity: | |
Reaction=ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate + H(+) + H2O; Xref=Rhea:RHEA:10152, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:28938, ChEBI:CHEBI:30616, ChEBI:CHEBI:58228, ChEBI:CHEBI:456216; EC=2.7.2.2; |
| Activity regulation: | |
Inhibited by adenosine(5')pentaphospho(5')adenosine (Ap5A), Ap6A and to a much lower extent by Ap4A. |
| Pathway: | |
Metabolic intermediate metabolism; carbamoyl phosphate degradation; CO(2) and NH(3) from carbamoyl phosphate: step 1/1. |
| Subunit: | |
Homodimer (predominantly) and homotetramer. |
| Subcellular location: | |
Cytoplasm {ECO:0000305}. |
| Induction: | |
By arginine. |
| Mass spectrometry: | |
Mass=32803; Mass_error=10; Method=Electrospray; Evidence={ECO:0000269|PubMed:9578487}; |
| Similarity: | |
Belongs to the carbamate kinase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.