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UniProt functional annotation for P10147 | ||
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| UniProt code: P10147. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose- dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). {ECO:0000269|PubMed:8525373}. |
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| Subunit: | |
Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69). {ECO:0000269|PubMed:12070155}. |
| Subcellular location: | |
Secreted. |
| Induction: | |
By TPA or PHA (TPA = 12-O-tetradecanoyl phorbol-13 acetate (tumor promoter); PHA = phytohemagglutinin (T-cell mitogen)). |
| Ptm: | |
N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells. |
| Similarity: | |
Belongs to the intercrine beta (chemokine CC) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.