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UniProt functional annotation for P30122 | ||
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| UniProt code: P30122. |
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| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
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| Function: | |
Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA) (PubMed:10220579). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). {ECO:0000250|UniProtKB:P19835, ECO:0000250|UniProtKB:Q64285, ECO:0000269|PubMed:10220579}. |
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| Catalytic activity: | |
Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence={ECO:0000250|UniProtKB:P19835}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12045; Evidence={ECO:0000250|UniProtKB:P19835}; |
| Catalytic activity: | |
Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)- octadecenoate + di-(9Z)-octadecenoylglycerol + H(+); Xref=Rhea:RHEA:38575, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:53753, ChEBI:CHEBI:75945; Evidence={ECO:0000269|PubMed:10220579}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38576; Evidence={ECO:0000305|PubMed:10220579}; |
| Catalytic activity: | |
Reaction=1,2,3-trioctanoylglycerol + H2O = dioctanoylglycerol + H(+) + octanoate; Xref=Rhea:RHEA:47864, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25646, ChEBI:CHEBI:76978, ChEBI:CHEBI:88066; Evidence={ECO:0000250|UniProtKB:P19835}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47865; Evidence={ECO:0000250|UniProtKB:P19835}; |
| Catalytic activity: | |
Reaction=a sterol ester + H2O = a fatty acid + a sterol + H(+); Xref=Rhea:RHEA:10100, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15889, ChEBI:CHEBI:28868, ChEBI:CHEBI:35915; EC=3.1.1.13; Evidence={ECO:0000250|UniProtKB:P19835}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10101; Evidence={ECO:0000250|UniProtKB:P19835}; |
| Catalytic activity: | |
Reaction=cholesteryl (9Z-octadecenoate) + H2O = (9Z)-octadecenoate + cholesterol + H(+); Xref=Rhea:RHEA:33875, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16113, ChEBI:CHEBI:30823, ChEBI:CHEBI:46898; Evidence={ECO:0000250|UniProtKB:P07882}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33876; Evidence={ECO:0000250|UniProtKB:P07882}; |
| Catalytic activity: | |
Reaction=an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+); Xref=Rhea:RHEA:12957, ChEBI:CHEBI:2571, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:47622; EC=3.1.1.6; Evidence={ECO:0000269|PubMed:10220579}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12958; Evidence={ECO:0000305|PubMed:10220579}; |
| Catalytic activity: | |
Reaction=a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+); Xref=Rhea:RHEA:47348, ChEBI:CHEBI:2571, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17968, ChEBI:CHEBI:50477; Evidence={ECO:0000250|UniProtKB:P07882}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47349; Evidence={ECO:0000250|UniProtKB:P07882}; |
| Catalytic activity: | |
Reaction=9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy- octadecanoate + H(+) + hexadecanoate; Xref=Rhea:RHEA:52052, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:83670, ChEBI:CHEBI:136286; Evidence={ECO:0000250|UniProtKB:P19835}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52053; Evidence={ECO:0000250|UniProtKB:P19835}; |
| Catalytic activity: | |
Reaction=9-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)- octadecenoate + 9-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52048, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:136282, ChEBI:CHEBI:136286; Evidence={ECO:0000250|UniProtKB:P19835}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52049; Evidence={ECO:0000250|UniProtKB:P19835}; |
| Catalytic activity: | |
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:40435, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:72998; Evidence={ECO:0000250|UniProtKB:P07882}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40436; Evidence={ECO:0000250|UniProtKB:P07882}; |
| Catalytic activity: | |
Reaction=12-hexadecanoyloxy-octadecanoate + H2O = 12- hydroxyoctadecanoate + H(+) + hexadecanoate; Xref=Rhea:RHEA:52056, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:83677, ChEBI:CHEBI:84201; Evidence={ECO:0000250|UniProtKB:Q64285}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52057; Evidence={ECO:0000250|UniProtKB:Q64285}; |
| Catalytic activity: | |
Reaction=12-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)- octadecenoate + 12-hydroxyoctadecanoate + H(+); Xref=Rhea:RHEA:52060, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:84201, ChEBI:CHEBI:136302; Evidence={ECO:0000250|UniProtKB:Q64285}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52061; Evidence={ECO:0000250|UniProtKB:Q64285}; |
| Catalytic activity: | |
Reaction=13-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)- octadecenoate + 13-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52064, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:136303, ChEBI:CHEBI:136304; Evidence={ECO:0000250|UniProtKB:Q64285}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52065; Evidence={ECO:0000250|UniProtKB:Q64285}; |
| Catalytic activity: | |
Reaction=9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)- hexadecenoate + 9-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52068, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:136286, ChEBI:CHEBI:136309; Evidence={ECO:0000250|UniProtKB:Q64285}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52069; Evidence={ECO:0000250|UniProtKB:Q64285}; |
| Catalytic activity: | |
Reaction=12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)- hexadecenoate + 12-hydroxyoctadecanoate + H(+); Xref=Rhea:RHEA:52072, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:84201, ChEBI:CHEBI:136312; Evidence={ECO:0000250|UniProtKB:Q64285}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52073; Evidence={ECO:0000250|UniProtKB:Q64285}; |
| Catalytic activity: | |
Reaction=13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)- hexadecenoate + 13-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52076, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:136304, ChEBI:CHEBI:136315; Evidence={ECO:0000250|UniProtKB:Q64285}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52077; Evidence={ECO:0000250|UniProtKB:Q64285}; |
| Catalytic activity: | |
Reaction=12-octadecanoyloxy-octadecanoate + H2O = 12- hydroxyoctadecanoate + H(+) + octadecanoate; Xref=Rhea:RHEA:52080, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:84201, ChEBI:CHEBI:136330; Evidence={ECO:0000250|UniProtKB:Q64285}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52081; Evidence={ECO:0000250|UniProtKB:Q64285}; |
| Catalytic activity: | |
Reaction=13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy- octadecanoate + H(+) + octadecanoate; Xref=Rhea:RHEA:52084, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:136304, ChEBI:CHEBI:136335; Evidence={ECO:0000250|UniProtKB:Q64285}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52085; Evidence={ECO:0000250|UniProtKB:Q64285}; |
| Catalytic activity: | |
Reaction=5-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)- hexadecenoate + 5-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52092, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:136369, ChEBI:CHEBI:136370; Evidence={ECO:0000250|UniProtKB:Q64285}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52093; Evidence={ECO:0000250|UniProtKB:Q64285}; |
| Catalytic activity: | |
Reaction=9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy- octadecanoate + H(+) + octadecanoate; Xref=Rhea:RHEA:52096, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:136286, ChEBI:CHEBI:136373; Evidence={ECO:0000250|UniProtKB:Q64285}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52097; Evidence={ECO:0000250|UniProtKB:Q64285}; |
| Activity regulation: | |
Activated by bile salts such as sodium taurocholate. {ECO:0000269|PubMed:10220579}. |
| Subunit: | |
Interacts with CLC. {ECO:0000250}. |
| Subcellular location: | |
Secreted {ECO:0000250|UniProtKB:P19835}. |
| Similarity: | |
Belongs to the type-B carboxylesterase/lipase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.