|
|
||
|
|
|
|
|
UniProt functional annotation for P04958 | ||
|
|
|
|
|
|
||
| UniProt code: P04958. |
|
||
| Organism: | |
Clostridium tetani (strain Massachusetts / E88). |
| Taxonomy: | |
Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae; Clostridium. |
|
||
|
||
| Function: | |
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2. |
|
||
| Catalytic activity: | |
Reaction=Hydrolysis of 76-Gln-|-Phe-77 bond in synaptobrevin 2.; EC=3.4.24.68; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250}; |
| Subunit: | |
The precursor polypeptide is subsequently cleaved to yield subchains L and H. These remain linked by a disulfide bridge and are non-toxic after separation. |
| Miscellaneous: | |
The C-terminus of the heavy chain binds to ganglioside receptors. |
| Similarity: | |
Belongs to the peptidase M27 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.