UniProt functional annotation for P02943



	UniProt functional annotation for P02943

UniProt code: P02943.

Organism: Escherichia coli (strain K12).

Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.

Function: Involved in the transport of maltose and maltodextrins (PubMed:3301537, PubMed:2832377, PubMed:11742115, PubMed:7824948, PubMed:8805519, PubMed:9299337). Indispensable for translocation of maltodextrins (alpha 1-4 linked polyglucosyls) containing more than three glucosyl moieties. A hydrophobic path ('greasy slide') of aromatic residues serves to guide and select the sugars for transport through the channel (PubMed:7824948, PubMed:8805519, PubMed:9299337, PubMed:11742115). Also acts as a receptor for several bacteriophages including lambda (PubMed:4201774). Binds maltosaccharides; when LamB binds starch in soft agar, it inhibits motility (PubMed:2832377). {ECO:0000269|PubMed:11742115, ECO:0000269|PubMed:2832377, ECO:0000269|PubMed:3301537, ECO:0000269|PubMed:4201774, ECO:0000269|PubMed:7824948, ECO:0000269|PubMed:8805519, ECO:0000269|PubMed:9299337}.

Subunit: Homotrimer formed of three 18-stranded antiparallel beta- barrels, containing three independent channels (PubMed:1988451, PubMed:16079137, PubMed:7824948, PubMed:8805519, PubMed:9299337) (By similarity). An intrasubunit disulfide bond contributes to trimer stability (PubMed:1988451). {ECO:0000255|HAMAP-Rule:MF_01301, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:1988451, ECO:0000269|PubMed:7824948, ECO:0000269|PubMed:8805519, ECO:0000269|PubMed:9299337}.

Subcellular location: Cell outer membrane {ECO:0000255|HAMAP- Rule:MF_01301, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:1988451, ECO:0000269|PubMed:4201774, ECO:0000269|Ref.9}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01301, ECO:0000269|PubMed:16079137}.

Induction: By maltose. {ECO:0000255|HAMAP-Rule:MF_01301, ECO:0000269|Ref.9}.

Disruption phenotype: Resistance to phage lambda (PubMed:4201774). No growth on dextrins (PubMed:2832377). {ECO:0000269|PubMed:2832377, ECO:0000269|PubMed:4201774}.

Similarity: Belongs to the porin LamB (TC 1.B.3) family. {ECO:0000255|HAMAP-Rule:MF_01301}.

Annotations taken from UniProtKB at the EBI.


Organism:		Escherichia coli (strain K12).
Taxonomy:		Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.



Function:		Involved in the transport of maltose and maltodextrins (PubMed:3301537, PubMed:2832377, PubMed:11742115, PubMed:7824948, PubMed:8805519, PubMed:9299337). Indispensable for translocation of maltodextrins (alpha 1-4 linked polyglucosyls) containing more than three glucosyl moieties. A hydrophobic path ('greasy slide') of aromatic residues serves to guide and select the sugars for transport through the channel (PubMed:7824948, PubMed:8805519, PubMed:9299337, PubMed:11742115). Also acts as a receptor for several bacteriophages including lambda (PubMed:4201774). Binds maltosaccharides; when LamB binds starch in soft agar, it inhibits motility (PubMed:2832377). {ECO:0000269\|PubMed:11742115, ECO:0000269\|PubMed:2832377, ECO:0000269\|PubMed:3301537, ECO:0000269\|PubMed:4201774, ECO:0000269\|PubMed:7824948, ECO:0000269\|PubMed:8805519, ECO:0000269\|PubMed:9299337}.


Subunit:		Homotrimer formed of three 18-stranded antiparallel beta- barrels, containing three independent channels (PubMed:1988451, PubMed:16079137, PubMed:7824948, PubMed:8805519, PubMed:9299337) (By similarity). An intrasubunit disulfide bond contributes to trimer stability (PubMed:1988451). {ECO:0000255\|HAMAP-Rule:MF_01301, ECO:0000269\|PubMed:16079137, ECO:0000269\|PubMed:1988451, ECO:0000269\|PubMed:7824948, ECO:0000269\|PubMed:8805519, ECO:0000269\|PubMed:9299337}.
Subcellular location:		Cell outer membrane {ECO:0000255\|HAMAP- Rule:MF_01301, ECO:0000269\|PubMed:16079137, ECO:0000269\|PubMed:1988451, ECO:0000269\|PubMed:4201774, ECO:0000269\|Ref.9}; Multi-pass membrane protein {ECO:0000255\|HAMAP-Rule:MF_01301, ECO:0000269\|PubMed:16079137}.
Induction:		By maltose. {ECO:0000255\|HAMAP-Rule:MF_01301, ECO:0000269\|Ref.9}.
Disruption phenotype:		Resistance to phage lambda (PubMed:4201774). No growth on dextrins (PubMed:2832377). {ECO:0000269\|PubMed:2832377, ECO:0000269\|PubMed:4201774}.
Similarity:		Belongs to the porin LamB (TC 1.B.3) family. {ECO:0000255\|HAMAP-Rule:MF_01301}.