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PDBsum entry 1ad2
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Ribosomal protein
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PDB id
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1ad2
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References listed in PDB file
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Key reference
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Title
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A mutant form of the ribosomal protein l1 reveals conformational flexibility.
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Authors
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J.Unge,
S.Al-Karadaghi,
A.Liljas,
B.H.Jonsson,
I.Eliseikina,
N.Ossina,
N.Nevskaya,
N.Fomenkova,
M.Garber,
S.Nikonov.
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Ref.
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Febs Lett, 1997,
411,
53-59.
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PubMed id
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Note In the PDB file this reference is
annotated as "TO BE PUBLISHED".
The citation details given above were identified by an automated
search of PubMed on title and author
names, giving a
percentage match of
86%.
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Abstract
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The crystal structure of the mutant S179C of the ribosomal protein L1 from
Thermus thermophilus has been determined at 1.9 A resolution. The mutant
molecule displays a small but significant opening of the cavity between the two
domains. The domain movement seems to be facilitated by the flexibility of at
least two conserved glycines. These glycines may be necessary for the larger
conformational change needed for an induced fit mechanism upon binding RNA. The
domain movement makes a disulfide bridge possible between the incorporated
cysteines in two monomers of the mutant L1.
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