PDBsum entry 1ab2

Transferase(phosphotransferase)

PDB id: 1ab2

Contents

Protein chain

109 a.a.

References listed in PDB file

Key reference

• Title: Three-Dimensional solution structure of the src homology 2 domain of c-Abl.
• Authors: M.Overduin, C.B.Rios, B.J.Mayer, D.Baltimore, D.Cowburn.
• Ref.: Cell, 1992, 70, 697-704. [DOI no: 10.1016/0092-8674(92)90437-H]
• PubMed id: 1505033

Abstract

SH2 regions are protein motifs capable of binding target protein sequences that contain a phosphotyrosine. The solution structure of the abl SH2 product, a protein of 109 residues and 12.1 kd, has been determined by multidimensional nuclear magnetic resonance spectroscopy. It is a compact spherical domain with a pair of three-stranded antiparallel beta sheets and a C-terminal alpha helix enclosing the hydrophobic core. Three arginines project from a short N-terminal alpha helix and one beta sheet into the putative phosphotyrosine-binding site, which lies on a face distal from the termini. Comparison with other SH2 sequences supports a common global fold and mode of phosphotyrosine binding for this family.

Secondary reference #1

• Title: Secondary structure of src homology 2 domain of c-Abl by heteronuclear nmr spectroscopy in solution.
• Authors: M.Overduin, B.Mayer, C.B.Rios, D.Baltimore, D.Cowburn.
• Ref.: Proc Natl Acad Sci U S A, 1992, 89, 11673-11677. [DOI no: 10.1073/pnas.89.24.11673]
• PubMed id: 1281542