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PDBsum entry 1a8a
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Phospholipid analog
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PDB id
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1a8a
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References listed in PDB file
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Key reference
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Title
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Ca(2+)-Bridging mechanism and phospholipid head group recognition in the membrane-Binding protein annexin V.
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Authors
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M.A.Swairjo,
N.O.Concha,
M.A.Kaetzel,
J.R.Dedman,
B.A.Seaton.
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Ref.
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Nat Struct Biol, 1995,
2,
968-974.
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PubMed id
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Abstract
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Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for
Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C,
and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V
complexes with phospholipid polar heads provide molecular details of
'Ca(2+)-bridges' as key features in the membrane attachment exhibited by these
proteins. Distinct binding sites for phospholipid head groups are observed,
including a novel, double-Ca2+ recognition site for phosphoserine that may serve
as a phosphatidylserine receptor site in vivo.
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