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UniProt functional annotation for P08921 | ||
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| UniProt code: P08921. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. {ECO:0000269|PubMed:2901293}. |
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| Subunit: | |
Interacts with CD48 (PubMed:16803907). Interacts with CD58 (LFA-3) (By similarity). Interacts with CD2AP (By similarity). Interacts with PSTPIP1 (By similarity). {ECO:0000250|UniProtKB:P06729, ECO:0000250|UniProtKB:P08920, ECO:0000269|PubMed:16803907}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:3102667}; Single-pass type I membrane protein {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.