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UniProt functional annotation for P14421 | ||
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| UniProt code: P14421. |
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| Organism: | |
Gloydius halys (Chinese water mocassin) (Agkistrodon halys). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Gloydius. |
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| Function: | |
Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. {ECO:0000269|PubMed:15032748}. |
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| Catalytic activity: | |
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence={ECO:0000255|PROSITE-ProRule:PRU10035, ECO:0000255|PROSITE- ProRule:PRU10036}; |
| Cofactor: | |
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000305|PubMed:10666574}; Note=Binds 1 Ca(2+) ion. {ECO:0000305|PubMed:10666574}; |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Mass spectrometry: | |
Mass=13938; Method=Electrospray; Evidence={ECO:0000269|PubMed:15032748}; |
| Similarity: | |
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.