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UniProt functional annotation for P14061 | ||
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| UniProt code: P14061. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:8994190). Also has 20-alpha-HSD activity. Uses preferentially NADH. {ECO:0000269|PubMed:8994190}. |
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| Catalytic activity: | |
Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH; Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62; Evidence={ECO:0000269|PubMed:8994190}; |
| Catalytic activity: | |
Reaction=17beta-estradiol + NADP(+) = estrone + H(+) + NADPH; Xref=Rhea:RHEA:24616, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.62; Evidence={ECO:0000250|UniProtKB:P51656}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:24618; Evidence={ECO:0000250|UniProtKB:P51656}; |
| Catalytic activity: | |
Reaction=NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH; Xref=Rhea:RHEA:14981, ChEBI:CHEBI:15378, ChEBI:CHEBI:16422, ChEBI:CHEBI:17347, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.51; Evidence={ECO:0000250|UniProtKB:P51656}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:14983; Evidence={ECO:0000250|UniProtKB:P51656}; |
| Biophysicochemical properties: | |
Kinetic parameters: KM=2.11 uM for 17beta-estradiol {ECO:0000269|PubMed:8994190}; KM=0.9 uM for estrone {ECO:0000269|PubMed:8994190}; |
| Pathway: | |
Steroid biosynthesis; estrogen biosynthesis. {ECO:0000269|PubMed:8994190}. |
| Subunit: | |
Homodimer. Exists predominantly as an homodimer but also exits as monomer. {ECO:0000269|PubMed:8805577, ECO:0000269|PubMed:8994190}. |
| Subcellular location: | |
Cytoplasm. |
| Similarity: | |
Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.