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PDBsum entry 1a1d
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Nucleotidyltransferase
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PDB id
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1a1d
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References listed in PDB file
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Key reference
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Title
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Eukaryotic RNA polymerase subunit rpb8 is a new relative of the ob family.
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Authors
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S.Krapp,
G.Kelly,
J.Reischl,
R.O.Weinzierl,
S.Matthews.
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Ref.
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Nat Struct Biol, 1998,
5,
110-114.
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PubMed id
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Abstract
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RNA polymerase II subunit RPB8 is an essential subunit that is highly conserved
throughout eukaryotic evolution and is present in all three types of nuclear RNA
polymerases. We report the first high resolution structural insight into
eukaryotic RNA polymerase architecture with the solution structure of RPB8 from
Saccharomyces cerevisiae. It consists of an eight stranded, antiparallel
beta-barrel, four short helical regions and a large, unstructured omega-loop.
The strands are connected in classic Greek-key fashion. The overall topology is
unusual and contains a striking C2 rotational symmetry. Furthermore, it is most
likely a novel associate of the oligonucleotide/oligosaccharide (OB) binding
protein class.
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Headers
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