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UniProt functional annotation for P07270 | ||
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| UniProt code: P07270. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Transcriptional activator that regulates the expression of repressible phosphatase under phosphate starvation conditions. Binds to the upstream activating sequence (UAS) of several phosphatase encoding PHO genes. Inhibited by the cyclin-CDK PHO80-PHO85 under high-phosphate conditions. |
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| Subunit: | |
Binds DNA as a homodimer. Interacts with transcription factor PHO2 and binds cooperatively to PHO5 UAS. Interacts with the cyclin-CDK PHO80-PHO85 and the CDK inhibitor (CKI) PHO81. {ECO:0000269|PubMed:7957107, ECO:0000269|PubMed:8187772}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:8539622}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:8539622}. Note=Predominantly cytoplasmic under high-phosphate conditions and localized to the nucleus upon phosphate starvation. |
| Domain: | |
The 9aaTAD motif (residues 75 to 83) is a transactivation domain present in a large number of yeast and animal transcription factors. {ECO:0000269|PubMed:17467953, ECO:0000269|PubMed:2183025}. |
| Ptm: | |
Phosphorylated by the cyclin-CDK PHO80-PHO85 at five residues under high-phosphate conditions, preventing PHO4 from activating the structural PHO genes. Phosphorylation of Ser-114 and Ser-128 promotes nuclear export. Phosphorylation of Ser-152 decreases nuclear import. Phosphorylation of Ser-223 decreases the binding affinity for PHO2. {ECO:0000269|PubMed:10320381, ECO:0000269|PubMed:8108735, ECO:0000269|PubMed:8539622}. |
| Sequence caution: | |
Sequence=CAA27345.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.