Ligand clusters for UniProt code Q07869

Ligand clusters for Q07869: Peroxisome proliferator-activated receptor alpha from Homo sapiens

		Top 6 (of 8) ligand clusters Cluster 1. 36 ligand types 73 ligands Cluster 2. 3 ligand types 7 ligands Cluster 3. 1 ligand type 2 ligands Cluster 4. 1 ligand type 4 ligands Cluster 5. 1 ligand type 19 ligands Cluster 6. 1 ligand type 1 ligand
Representative protein: 6lx5A

Structures

PDB		Schematic diagram
6lx5A
2rewA
7c6qA
6lxbA
5aztA
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Cluster 1 contains 36 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: F5A × 5 fenofibric acid 2-[4-(4-Chlorobenzene-1-Carbonyl)phenoxy]-2- Methylpropanoic acid PDB codes: 6l36(A), 6lx4(A), 7bq0(A),
		2. Ligand: PLM × 3 palmitic acid Palmitic acid PDB codes: 6kax(A), 6lx6(A), 7bq1(A).
		3. Ligand: EPA × 2 icosapent 5,8,11,14,17-Eicosapentaenoic acid PDB codes: 6lxa(A), 7bq4(A).
		4. Ligand: IL2 × 1 iloprost (5e)-5-[(3as,4r,5r,6as)-5-Hydroxy-4-[(1e,3s,4r)-3- Hydroxy-4-Methyloct-1-En-6-Yn-1- Yl]hexahydropentalen- 2(1h)-Ylidene]pentanoic acid PDB code: 3sp6(A).
		5. Ligand: PEM × 1 bezafibrate 2-[P-[2-P-Chlorobenzamido)ethyl]phenoxy]-2- Methylpropionic acid PDB code: 7bpz(A).
		6. Ligand: STE × 1 stearic acid Stearic acid PDB code: 6lx7(A).
		7. Ligand: GW9 × 11 2-Chloro-5-Nitro-N-Phenylbenzamide PDB codes: 6kyp(A), 6l36(A), 6l37(A), 6l38(A),
		8. Ligand: WY1 × 8 2-({4-Chloro-6-[(2,3-Dimethylphenyl)amino] pyrimidin-2-Yl}sulfanyl)acetic acid PDB codes: 4bcr(A), 6kb2(A), 6kb7(A), 6kba(A),
		9. Ligand: P7F × 5 (2~{r})-2-[3-[[1,3-Benzoxazol-2-Yl-[3-(4- Methoxyphenoxy)propyl]amino]methyl]phenoxy]butanoic acid PDB codes: 6kaz(A), 6kb4(A), 6kb9(A), 6l96(A), 7bq2(A).
		10. Ligand: 2VN × 4 2-[(4-{2-[(4-Cyclohexylbutyl)(cyclohexylcarbamoyl) amino]ethyl}phenyl)sulfanyl]-2- Methylpropanoic acid PDB codes: 6kay(A), 6kb3(A), 6kb8(A), 7bq3(A).
		11. Ligand: C5F × 3 2-{4-[(1s)-2,2-Dichlorocyclopropyl]phenoxy}-2- Methylpropanoic acid PDB codes: 6l37(A), 6lx5(A),
		12. Ligand: E0O × 2 2-(4-Chloranylphenoxy)-2-Methyl-Propanoic acid PDB codes: 7bpy(A),
		13. Ligand: EWR × 2 (2s)-2-Ethoxy-3-[4-[2-[2-Methyl-5-(4- Methylsulfanylphenyl)pyrrol-1- Yl]ethoxy]phenyl]propanoic acid PDB codes: 6lxb(A), 6lxc(A).
		14. Ligand: ITY × 2 Icosa-5,8,11,14-Tetraynoic acid PDB codes: 6kb0(A), 6kb5(A).
		15. Ligand: T4T × 2 2-Tetradecylsulfanylethanoic acid PDB codes: 6kb1(A), 6kb6(A).
		16. Ligand: 13M × 1 (2s)-2-(4-Methoxy-3-{[(Pyren-1-Ylcarbonyl) amino]methyl}benzyl)butanoic acid PDB code: 3vi8(A).
		17. Ligand: 471 × 1 N-((2s)-2-({(1z)-1-Methyl-3-Oxo-3-[4-(Trifluoromethyl) phenyl]prop-1-Enyl}amino)-3-{4-[2-(5-Methyl- 2-Phenyl- 1,3-Oxazol-4-Yl)ethoxy]phenyl}propyl)propanamide PDB code: 1kkq(A).
		18. Ligand: 4M5 × 1 (4~{z},7~{z},10~{z},13~{z},19~{z})-17- Oxidanylidenedocosa-4,7,10,13,19-Pentaenoic acid PDB code: 5azt(A).
		19. Ligand: 544 × 1 2-(1-Methyl-3-Oxo-3-Phenyl-Propylamino)-3-{4-[2-(5- Methyl-2-Phenyl-Oxazol-4-Yl)-Ethoxy]-Phenyl}- Propionic acid PDB code: 1k7l(A).
		20. Ligand: 65W × 1 2-Methyl-2-[4-(Naphthalen-1-Yl)phenoxy]propanoic acid PDB code: 5hyk(A).
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Cluster 2 contains 3 ligand types

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Ligand		Description
		1. Ligand: ARG-HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN × 4 PDB codes: 6l96(A), 7bq1(A), 7bq2(A), 7bq4(A).
		2. Ligand: HIS-GLN-LEU-LEU-ARG-TYR-LEU-LEU × 2 PDB codes: 3fei(A), 3g8i(A).
		3. Ligand: LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN × 1 PDB code: 7c6q(A).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: CPQ × 2 N,N-Bis(3-D-Gluconamidopropyl)deoxycholamide PDB codes: 1i7g(A), 2rew(A).

Cluster 4 contains 1 ligand type

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Ligand		Description
		1. Ligand: GW9 × 4 2-Chloro-5-Nitro-N-Phenylbenzamide PDB codes: 6kyp(A), 6l36(A), 6l37(A),

Cluster 5 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 19 glycerin Glycerol PDB codes: 6kax(A), 6kay(A), 6kaz(A), 6kb0(A), 6kb1(A), 6kb3(A), 6kb4(A), 6kb5(A), 6kb6(A), 6kb8(A), 6kb9(A), 6lx6(A), 6lx7(A), 6lx8(A), 6lx9(A), 6lxa(A), 7bq1(A), 7bq2(A), 7bq4(A).

Cluster 6 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 6lx5(A).