 |
| PDB id |
|
Count |
|
Name |
|
Method |
|
Date |
|
|
|
|
×1
|
|
Crystal structure analysis of delta-chymotrypsin bound to a peptidyl chloromethyl ketone inhibitor
|
|
X-ray(2.14Å)
|
|
03-May-00
|
|
|
|
×5
|
|
Caspase-8 specificity probed at subsite s4: crystal structure of the caspase-8-z-devd-cho
|
|
X-ray(2.9Å)
|
|
10-Jul-01
|
|
|
|
×0
|
|
Glycyl endopeptidase-complex with benzyloxycarbonyl-leucine-valine- glycine-methylene covalently bound to cysteine 25
|
|
X-ray(2.1Å)
|
|
07-Dec-95
|
|
|
|
×1
|
|
Structure of cleaved, card domain deleted caspase-9
|
|
X-ray(2.8Å)
|
|
12-Dec-01
|
|
|
|
×0
|
|
Thermolysin complexed with z-l-threonine (benzyloxycarbonyl-l- threonine)
|
|
X-ray(1.6Å)
|
|
05-Dec-02
|
|
|
|
×0
|
|
Thermolysin complexed with z-l-glutamic acid (benzyloxycarbonyl-l- glutamic acid)
|
|
X-ray(1.6Å)
|
|
05-Dec-02
|
|
|
|
×0
|
|
Thermolysin complexed with z-l-aspartic acid (benzyloxycarbonyl-l- aspartic acid)
|
|
X-ray(1.6Å)
|
|
10-Dec-02
|
|
|
|
×0
|
|
Thermolysin complexed with z-l-alanine (benzyloxycarbonyl-l-alanine)
|
|
X-ray(1.8Å)
|
|
11-Dec-02
|
|
|
|
×0
|
|
Thermolysin complexed with z-d-glutamic acid (benzyloxycarbonyl-d- glutamic acid)
|
|
X-ray(1.8Å)
|
|
09-Jan-03
|
|
|
|
×0
|
|
Thermolysin complexed with z-d-threonine (benzyloxycarbonyl-d- threonine)
|
|
X-ray(1.7Å)
|
|
10-Jan-03
|
|
|
|
×0
|
|
Thermolysin complexed with z-d-aspartic acid (benzyloxycarbonyl-d- aspartic acid)
|
|
X-ray(1.7Å)
|
|
11-Jan-03
|
|
|
|
×0
|
|
Thermolysin complexed with z-d-alanine (benzyloxycarbonyl-d-alanine)
|
|
X-ray(1.9Å)
|
|
17-Jan-03
|
|
|
|
×5
|
|
Crystal structure of the complex of caspase-8 with the tripeptide ketone inhibitor zevd-dcbmk
|
|
X-ray(2.8Å)
|
|
10-Jul-00
|
|
|
|
×0
|
|
Design of specific inhibitors of phopholipase a2: crystal structure of the complex formed between group ii phopholipase a2 and a designed peptide dehydro-ile-ala-arg-ser at 1.2a resolution
|
|
X-ray(1.2Å)
|
|
13-Apr-04
|
|
|
|
×0
|
|
Crystal structure of the complex formed between russells viper phospholipase a2 and a designed peptide inhibitor phq-leu-val-arg-tyr at 1.2a resolution
|
|
X-ray(1.25Å)
|
|
08-Jun-04
|
|
|
|
×0
|
|
Crystal structure of the complex formed between a group ii phospholipase a2 and designed peptide inhibitor carbobenzoxy-dehydro-val-ala-arg-ser at 1.2 a resolution
|
|
X-ray(1.25Å)
|
|
22-Jun-04
|
|
|
|
×0
|
|
Crystal structures of caspase-3 in complex with aza-peptide michael acceptor inhibitors.
|
|
X-ray(1.77Å)
|
|
20-Sep-06
|
|
|
|
×0
|
|
Crystal structures of caspase-3 in complex with aza-peptide michael acceptor inhibitors.
|
|
X-ray(1.87Å)
|
|
20-Sep-06
|
|
|
|
×0
|
|
Crystal structures of caspase-3 in complex with aza-peptide michael acceptor inhibitors.
|
|
X-ray(1.94Å)
|
|
20-Sep-06
|
|
|
|
×0
|
|
Crystal structures of caspase-3 in complex with aza-peptide michael acceptor inhibitors.
|
|
X-ray(2.45Å)
|
|
20-Sep-06
|
|
|
|
×0
|
|
Crystal structure of caspase-8 in complex with aza-peptide michael acceptor inhibitor
|
|
X-ray(1.95Å)
|
|
20-Sep-06
|
|
|
|
×0
|
|
Crystal structures of caspase-3 in complex with aza-peptide epoxide inhibitors.
|
|
X-ray(1.7Å)
|
|
20-Mar-07
|
|
|
|
×0
|
|
Extended substrate recognition in caspase-3 revealed by high resolution x-ray structure analysis
|
|
X-ray(1.67Å)
|
|
27-Jun-06
|
|
|
|
×0
|
|
Crystal structures of caspase-3 in complex with aza-peptide epoxide inhibitors.
|
|
X-ray(1.75Å)
|
|
22-May-07
|
|
|
|
×0
|
|
Crystal structures of caspase-3 in complex with aza-peptide epoxide inhibitors.
|
|
X-ray(1.67Å)
|
|
22-May-07
|
|
|
|
×0
|
|
Crystal structures of caspase-3 in complex with aza-peptide epoxide inhibitors.
|
|
X-ray(1.7Å)
|
|
22-May-07
|
|
|
|
×0
|
|
Crystal structures of caspase-3 in complex with aza-peptide epoxide inhibitors.
|
|
X-ray(1.95Å)
|
|
22-May-07
|
|
|
|
×0
|
|
The mouse pngase-hr23 complex reveals a complete remodulation of the protein-protein interface compared to its yeast orthologs
|
|
X-ray(2.26Å)
|
|
07-Mar-06
|
|
|
|
×0
|
|
Crystal structure of a complex of phospholipase a2 with a designed peptide inhibitor dehydro-ile-ala-arg-ser at 0.98 a resolution
|
|
X-ray(0.98Å)
|
|
28-Mar-06
|
|
|
|
×0
|
|
Crystal structure of human caspase-1 (cys362->ala, cys364->ala, cys397->ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl- butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-vad-fmk)
|
|
X-ray(2.2Å)
|
|
06-Jun-06
|
|
|
|
×0
|
|
Crystal structure of human caspase-1 (glu390->asp) in complex with 3- [2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]- 4-oxo-pentanoic acid (z-vad-fmk)
|
|
X-ray(2Å)
|
|
11-Mar-08
|
|
|
|
×0
|
|
Crystal structure of human caspase-1 (arg286->lys) in complex with 3- [2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]- 4-oxo-pentanoic acid (z-vad-fmk)
|
|
X-ray(1.9Å)
|
|
11-Mar-08
|
|
|
|
×0
|
|
Crystal structure of human caspase-1 (glu390->asp and arg286->lys) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)- propionylamino]-4-oxo-pentanoic acid (z-vad-fmk)
|
|
X-ray(2.1Å)
|
|
11-Mar-08
|
|
|
|
×0
|
|
Crystal structure of human caspase-1 (thr388->ala) in complex with 3- [2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]- 4-oxo-pentanoic acid (z-vad-fmk)
|
|
X-ray(1.8Å)
|
|
11-Mar-08
|
|
|
|
×0
|
|
Crystal structure of wildtype human caspase-1 in complex with 3-[2-(2- benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo- pentanoic acid (z-vad-fmk)
|
|
X-ray(1.8Å)
|
|
27-Jun-06
|
|
|
|
×0
|
|
Crystal structure of human caspase-1 (arg286->ala) in complex with 3- [2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]- 4-oxo-pentanoic acid (z-vad-fmk)
|
|
X-ray(2.2Å)
|
|
27-Jun-06
|
|
|
|
×0
|
|
Crystal structure of human caspase-1 (glu390->ala) in complex with 3- [2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]- 4-oxo-pentanoic acid (z-vad-fmk)
|
|
X-ray(2.1Å)
|
|
27-Jun-06
|
|
|
|
×0
|
|
Crystal structure of human caspase-1 (arg286->ala, glu390->ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)- propionylamino]-4-oxo-pentanoic acid (z-vad-fmk)
|
|
X-ray(1.9Å)
|
|
27-Jun-06
|
|
|
|
×0
|
|
Solution structure of the s. Aureus sortase a-substrate complex
|
|
NMR(20 models)
|
|
21-Jul-09
|
|
|
|
×0
|
|
Complex structure of dvl pdz domain with ligand
|
|
NMR(20 models)
|
|
30-Dec-15
|
|
|
|
×0
|
|
Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide
|
|
X-ray(1.35Å)
|
|
23-Jun-10
|
|
|
|
×0
|
|
Crystal structure of human caspase-1 with a naturally-occurring arg240->gln substitution in complex with 3-[2-(2- benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo- pentanoic acid (z-vad-fmk)
|
|
X-ray(1.9Å)
|
|
02-Mar-10
|
|
|
|
×0
|
|
Crystal structure of human caspase-1 with a naturally-occurring asn263->ser substitution in complex with 3-[2-(2- benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo- pentanoic acid (z-vad-fmk)
|
|
X-ray(2Å)
|
|
02-Mar-10
|
|
|
|
×0
|
|
Crystal structure of human caspase-1 with a naturally-occurring lys319->arg substitution in complex with 3-[2-(2- benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo- pentanoic acid (z-vad-fmk)
|
|
X-ray(1.8Å)
|
|
02-Mar-10
|
|
|
|
×0
|
|
Crystal structure of the complex formed between a group ii phospholipase a2 and designed peptide inhibitor carbobenzoxy-dehydro- val-ala-arg-ser at 1.2 a resolution
|
|
X-ray(1.25Å)
|
|
10-Mar-09
|
|
|
|
×2
|
|
Caspase-6 in complex with z-vad-fmk inhibitor
|
|
X-ray(2.65Å)
|
|
21-Sep-11
|
|
|
|
×0
|
|
Transglutaminase 2 in complex with a novel inhibitor
|
|
X-ray(2.25Å)
|
|
06-Jun-12
|
|
|
|
×0
|
|
Transglutaminase 2 in complex with a novel inhibitor
|
|
X-ray(2.5Å)
|
|
06-Jun-12
|
|
|
|
×0
|
|
Transglutaminase 2 in complex with a novel inhibitor
|
|
X-ray(2.3Å)
|
|
06-Jun-12
|
|
|
|
×0
|
|
Mouse malt1(caspase-ig3 domains) in complex with a irreversible peptidic inhibitor
|
|
X-ray(3.15Å)
|
|
14-Mar-12
|
|
|
|
×0
|
|
Human malt1 (caspase domain) in complex with an irreversible peptidic inhibitor
|
|
X-ray(2.1Å)
|
|
14-Mar-12
|
|
|
|
×1
|
|
Crystal structure of sars-cov 3c-like protease with c4z
|
|
X-ray(1.95Å)
|
|
12-Dec-12
|
|
|
|
×1
|
|
Crystal structure of active legumain in complex with aan-cmk
|
|
X-ray(2.7Å)
|
|
26-Jun-13
|
|
|
|
×1
|
|
The crystal structure of ubiquitin carboxy-terminal hydrolase l1 (uchl1) bound to a tripeptide fluoromethyl ketone z-vae(ome)-fmk
|
|
X-ray(2.35Å)
|
|
23-May-12
|
|
|
|
×1
|
|
Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6
|
|
X-ray(2.07Å)
|
|
20-Mar-13
|
|
|
|
×0
|
|
Structural basis of substrate specificity and protease inhibition in norwalk virus
|
|
X-ray(1.5Å)
|
|
20-Feb-13
|
|
|
|
×0
|
|
Structural basis of substrate specificity and protease inhibition in norwalk virus
|
|
X-ray(1.7Å)
|
|
20-Feb-13
|
|
|
|
×7
|
|
Structural basis of substrate specificity and protease inhibition in norwalk virus
|
|
X-ray(1.7Å)
|
|
20-Feb-13
|
|
|
|
×3
|
|
Staphylococcus aureus sortase b-substrate complex
|
|
X-ray(2.49Å)
|
|
12-Feb-14
|
|
|
|
×0
|
|
Grb2 sh2 complexed with a ptyr-ac6cn-asn tripeptide
|
|
X-ray(1.64Å)
|
|
18-Jun-14
|
|
|
|
×0
|
|
Protein-protein interaction
|
|
X-ray(1.99Å)
|
|
31-May-17
|
|
|
|
×0
|
|
Moa-z-vad-fmk complex, direct orientation
|
|
X-ray(1.6Å)
|
|
02-Mar-16
|
|
|
|
×0
|
|
Moa-z-vad-fmk complex, inverted orientation
|
|
X-ray(1.7Å)
|
|
02-Mar-16
|
|
|
|
×0
|
|
Moa-z-vad-fmk inhibitor complex, direct/inverted dual orientation
|
|
X-ray(1.65Å)
|
|
02-Mar-16
|
|
|
|
×0
|
|
Protein-protein interaction
|
|
X-ray(2.15Å)
|
|
05-Jul-17
|
|
|
|
×1
|
|
Human 20s proteasome complex with z-lly-ketoaldehyde at 2.1 angstrom
|
|
X-ray(2.07Å)
|
|
17-Aug-16
|
|
|
|
×0
|
|
Binding of chloromethyl ketone substrate analogues to crystalline papain
|
|
X-ray(2.8Å)
|
|
12-Apr-77
|
|
|
|
×3
|
|
Crystal structure of p450bm3 with benzyloxycarbonyl-l-prolyl-l- phenylalanine
|
|
X-ray(2.2Å)
|
|
21-Feb-18
|
|
|
|
×0
|
|
Crystal structure of sirt5 complexed with a fluorogenic small-molecule substrate subka
|
|
X-ray(2.19Å)
|
|
02-May-18
|
|
|
|
×1
|
|
Crystal structure of af9 yeats domain in complex with a peptide inhibitor "phq-h3(q5-k9)" modified at k9 with 2-furancarboyl group
|
|
X-ray(1.9Å)
|
|
07-Nov-18
|
|
|
|
×0
|
|
Crystal structure of the prefusion form of measles virus fusion protein in complex with a fusion inhibitor peptide (fip)
|
|
X-ray(2.64Å)
|
|
21-Feb-18
|
|
|
|
×0
|
|
Apc with an inhibitor
|
|
X-ray(1.79Å)
|
|
06-Feb-19
|
|
|
|
×0
|
|
Sars-cov-2 main protease in a covalent complex with sdz 224015 derivative, compound 5
|
|
X-ray(1.7Å)
|
|
07-Jul-21
|
|
|
|
×0
|
|
Crystal structure of the sars-cov-2 main protease in complex with z- vad(ome)-fmk
|
|
X-ray(2.2Å)
|
|
02-Sep-20
|
|
|
|
×0
|
|
Crystal structure of the sars-cov-2 (covid-19) main protease in complex with z-vad-fmk
|
|
X-ray(1.82Å)
|
|
23-Jun-21
|
|
|
|
×0
|
|
Apc-asef fp assay tracer
|
|
X-ray(2.8Å)
|
|
06-Jul-22
|
|
|
|
×0
|
|
Sars-cov-2 main protease in complex with z-vad-fmk
|
|
X-ray(1.8Å)
|
|
22-Mar-23
|
|
