Ligand clusters for UniProt code P49366

Ligand clusters for P49366: Deoxyhypusine synthase from Homo sapiens

		Top 6 (of 38) ligand clusters Cluster 1. 10 ligand types 51 ligands Cluster 2. 3 ligand types 3 ligands Cluster 3. 3 ligand types 3 ligands Cluster 4. 2 ligand types 4 ligands Cluster 5. 3 ligand types 6 ligands Cluster 6. 2 ligand types 2 ligands
Representative protein: 6xxjA

Structures

PDB		Schematic diagram
6xxjA
6xxmA
6xxkA
6xxhA
6xxmB
		more ...

Cluster 1 contains 10 ligand types

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Ligand		Description
		1. Ligand: NAD × 4 Nicotinamide-Adenine-Dinucleotide PDB codes: 1dhs(A), 1rlz(A), 1roz(A), 1rqd(A).
		2. Ligand: GC7 × 1 1-Guanidinium-7-Aminoheptane PDB code: 1rqd(A).
		3. Ligand: NAD × 8 Nicotinamide-Adenine-Dinucleotide PDB codes: 6p4v(A), 6xxi(A), 6xxj(A),
		4. Ligand: EDO × 10 1,2-Ethanediol PDB codes: 6xxi(A), 6xxk(A), 6xxl(A),
		5. Ligand: SPD × 8 Spermidine PDB codes: 6xxj(A), 6xxk(A),
		6. Ligand: BME × 7 Beta-Mercaptoethanol PDB codes: 6xxh(A), 6xxi(A), 6xxj(A), 6xxk(A),
		7. Ligand: ACT × 5 Acetate ion PDB codes: 6xxk(A), 6xxl(A).
		8. Ligand: PUT × 4 1,4-Diaminobutane PDB codes: 6xxm(A),
		9. Ligand: GC7 × 2 1-Guanidinium-7-Aminoheptane PDB codes: 6p4v(A),
		10. Ligand: SPM × 2 Spermine PDB codes: 6xxl(A),

Cluster 2 contains 3 ligand types

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Ligand		Description
		1. Ligand: 8XY × 1 6-Bromo-N-(1h-Indol-4-Yl)-1-Benzothiophene-2- Carboxamide PDB code: 6pgr(A).
		2. Ligand: 8Y1 × 1 6-[(1r)-2-Amino-1-Phenylethyl]-3-(Pyridin-3-Yl)-5,6- Dihydrothieno[2,3-C]pyridin-7(4h)-One PDB code: 6wkz(A).
		3. Ligand: 91A × 1 6-[(2r)-1-Amino-4-Methylpentan-2-Yl]-3-(Pyridin-3-Yl)- 5,6-Dihydrothieno[2,3-C]pyridin-7(4h)-One PDB code: 6wl6(A).

Cluster 3 contains 3 ligand types

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Ligand		Description
		1. Ligand: 8XY × 1 6-Bromo-N-(1h-Indol-4-Yl)-1-Benzothiophene-2- Carboxamide PDB code: 6pgr(A).
		2. Ligand: 8Y1 × 1 6-[(1r)-2-Amino-1-Phenylethyl]-3-(Pyridin-3-Yl)-5,6- Dihydrothieno[2,3-C]pyridin-7(4h)-One PDB code: 6wkz(A).
		3. Ligand: 91A × 1 6-[(2r)-1-Amino-4-Methylpentan-2-Yl]-3-(Pyridin-3-Yl)- 5,6-Dihydrothieno[2,3-C]pyridin-7(4h)-One PDB code: 6wl6(A).

Cluster 4 contains 2 ligand types

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Ligand		Description
		1. Ligand: MPD × 2 (4s)-2-Methyl-2,4-Pentanediol PDB codes: 6p4v(A), 6xxm(B).
		2. Ligand: MRD × 2 (4r)-2-Methylpentane-2,4-Diol PDB codes: 6xxj(B), 6xxk(B).

Cluster 5 contains 3 ligand types

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Ligand		Description
		1. Ligand: ACT × 3 Acetate ion PDB codes: 6xxi(A), 6xxj(B), 6xxk(B).
		2. Ligand: BME × 2 Beta-Mercaptoethanol PDB codes: 6xxj(A), 6xxk(A).
		3. Ligand: OXM × 1 Oxamic acid PDB code: 6xxl(A).

Cluster 6 contains 2 ligand types

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Ligand		Description
		1. Ligand: ACT × 1 Acetate ion PDB code: 6xxj(B).
		2. Ligand: PGE × 1 Triethylene glycol PDB code: 6xxj(B).