Ligand clusters for UniProt code P48736

Ligand clusters for P48736: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform from Homo sapiens

		Top 6 (of 10) ligand clusters Cluster 1. 97 ligand types 99 ligands Cluster 2. 2 ligand types 21 ligands Cluster 3. 1 ligand type 30 ligands Cluster 4. 1 ligand type 10 ligands Cluster 5. 1 ligand type 24 ligands Cluster 6. 1 ligand type 1 ligand
Representative protein: 3ibeA

Structures

PDB		Schematic diagram
3ibeA
4fa6A
4aofA
5kaeA
4wwpA
		more ...

Cluster 1 contains 97 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: 6E2 × 1 copanlisib 2-Azanyl-~{N}-[7-Methoxy-8-(3-Morpholin-4- Ylpropoxy)-2,3-Dihydroimidazo[1,2-C]quinazolin- 5- Yl]pyrimidine-5-Carboxamide PDB code: 5g2n(A).
		2. Ligand: STU × 1 Staurosporine PDB code: 1e8z(A).
		3. Ligand: 039 × 1 2-((9h-Purin-6-Ylthio)methyl)-5-Chloro-3-(2- Methoxyphenyl)quinazolin-4(3h)-One PDB code: 2chw(A).
		4. Ligand: 090 × 1 N-(2,3-Dihydro-7,8-Dimethoxyimidazo[1,2-C] quinazolin- 5-Yl)nicotinamide PDB code: 2chx(A).
		5. Ligand: QYT × 1 (5e)-5-(Quinoxalin-6-Ylmethylene)-1,3-Thiazolidine-2,4- Dione PDB code: 2a5u(A).
		6. Ligand: 093 × 1 N-(5-(4-Chloro-3-(2-Hydroxy-Ethylsulfamoyl)- Phenylthiazole-2-Yl)-Acetamide PDB code: 2chz(A).
		7. Ligand: BYM × 1 (5e)-5-[(2,2-Difluoro-1,3-Benzodioxol-5-Yl)methylene]- 1,3-Thiazolidine-2,4-Dione PDB code: 2a4z(A).
		8. Ligand: DD8 × 2 3-Methyl-1-(Oxan-4-Yl)-8-Pyridin-3-Yl-Imidazo[4,5- C]quinolin-2-One PDB codes: 6fh5(A), 6gq7(A).
		9. Ligand: V7Y × 2 2-Amino-N-[(1s)-1-{8-[(1-Methyl-1h-Pyrazol-4-Yl) ethynyl]-1-Oxo-2-Phenyl-1,2-Dihydroisoquinolin-3- Yl}ethyl]pyrazolo[1,5-A]pyrimidine-3-Carboxamide PDB codes: 6xrl(A), 7jwz(A).
		10. Ligand: 0KO × 1 4-(2-[(6-Methoxypyridin-3-Yl)amino]-5-{[4- (Methylsulfonyl)piperazin-1-Yl]methyl}pyridin-3-Yl)-6- Methyl-1,3,5-Triazin-2-Amine PDB code: 4dk5(A).
		11. Ligand: 0SC × 1 2-(1-{[2-(5-Fluoro-1h-Indol-4-Yl)-4-(Morpholin-4-Yl) pyrido[3,2-D]pyrimidin-6-Yl]methyl}piperidin- 4-Yl) propan-2-Ol PDB code: 4ezj(A).
		12. Ligand: 0SD × 1 2-(1-{[2-(2h-Indazol-4-Yl)-4-(Morpholin-4-Yl)pyrido[3, 2-D]pyrimidin-6-Yl]methyl}piperidin-4- Yl)propan-2-Ol PDB code: 4ezk(A).
		13. Ligand: 0SE × 1 2-(1-{[2-(2-Aminopyrimidin-5-Yl)-4-(Morpholin-4-Yl) pyrido[3,2-D]pyrimidin-6-Yl]methyl}piperidin-4- Yl) propan-2-Ol PDB code: 4ezl(A).
		14. Ligand: 0TA × 1 2-Amino-8-Cyclopentyl-4-Methyl-6-(1h-Pyrazol-4-Yl) pyrido[2,3-D]pyrimidin-7(8h)-One PDB code: 4fa6(A).
		15. Ligand: 0TB × 1 2-Amino-6-(5-Fluoro-6-Methoxypyridin-3-Yl)-4-Methyl-8- (Pyrrolidin-1-Yl)pyrido[2,3-D]pyrimidin- 7(8h)-One PDB code: 4fad(A).
		16. Ligand: 0TZ × 1 3-(4-Amino-6-Methyl-1,3,5-Triazin-2-Yl)-N-(1h-Pyrazol- 5-Yl)imidazo[1,2-A]pyridin-2-Amine PDB code: 4fhj(A).
		17. Ligand: 0U0 × 1 3-[2-Methyl-6-(Pyrazin-2-Ylamino)pyrimidin-4-Yl]-N-(1h- Pyrazol-3-Yl)imidazo[1,2-B]pyridazin-2- Amine PDB code: 4fhk(A).
		18. Ligand: 0VU × 1 4-({4-[3-(Piperidin-1-Ylcarbonyl)phenyl]pyrimidin-2- Yl}amino)benzenesulfonamide PDB code: 4ful(A).
		19. Ligand: 0W7 × 1 2-[4-(Morpholin-4-Yl)-6-Oxo-1,6-Dihydropyrimidin-2-Yl]- N-Phenylacetamide PDB code: 4g11(A).
		20. Ligand: 0WR × 1 2-[1-({2-[2-(Dimethylamino)-1h-Benzimidazol-1-Yl]-9- Methyl-6-(Morpholin-4-Yl)-9h-Purin-8- Yl}methyl) piperidin-4-Yl]propan-2-Ol PDB code: 4gb9(A).
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Cluster 2 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 4wwp(A).
		2. Ligand: SO4 × 20 Sulfate ion PDB codes: 3qaq(A), 3qk0(A), 3s2a(A), 3tjp(A), 4f1s(A), 4fhj(A), 4fhk(A), 4fjy(A), 4fjz(A), 4flh(A), 4kz0(A), 4kzc(A), 4wwo(A), 4wwp(A), 5eds(A), 5jha(A), 5kae(A), 6c1s(A), 6xrl(A), 6xrm(A).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: SO4 × 30 Sulfate ion PDB codes: 3apc(A), 3apd(A), 3apf(A), 3ibe(A), 3l08(A), 3lj3(A), 3qaq(A), 3qar(A), 3qjz(A), 3qk0(A), 3s2a(A), 4anu(A), 4anv(A), 4anw(A), 4dk5(A), 4f1s(A), 4fhj(A), 4fhk(A), 4fjy(A), 4fjz(A), 4flh(A), 4wwn(A), 4wwo(A), 4wwp(A), 5eds(A), 5g55(A), 5jha(A), 5jhb(A), 5kae(A), 6c1s(A).

Cluster 4 contains 1 ligand type

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Ligand		Description
		1. Ligand: SO4 × 10 Sulfate ion PDB codes: 3apc(A), 3apd(A), 3apf(A), 3qar(A), 4fhj(A), 4fhk(A), 4fjz(A), 4flh(A), 4wwo(A), 6c1s(A).

Cluster 5 contains 1 ligand type

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Ligand		Description
		1. Ligand: SO4 × 24 Sulfate ion PDB codes: 3l08(A), 3l54(A), 3lj3(A), 3qaq(A), 3qar(A), 3qk0(A), 3s2a(A), 4dk5(A), 4f1s(A), 4fhj(A), 4fhk(A), 4fjy(A), 4fjz(A), 4flh(A), 4wwn(A), 4wwo(A), 4wwp(A), 5eds(A), 5g2n(A), 5jha(A), 5kae(A), 6c1s(A), 6xrl(A), 6xrm(A).

Cluster 6 contains 1 ligand type

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Ligand		Description
		1. Ligand: SO4 × 1 Sulfate ion PDB code: 4dk5(A).